Metabolic & GLP-1 peptides

GLP-1 (glucagon-like peptide-1) is an incretin hormone that stimulates insulin secretion and influences appetite. Engineered analogs dominat…

Semaglutide is a modified GLP-1 receptor agonist peptide designed for extended half-life. It is an approved prescription medicine in many ju…

MOTS-c is a 16-amino-acid mitochondrial-derived peptide studied in metabolic stress and exercise-related experimental models.

Exendin-4 is a 39-residue peptide from Gila monster venom that activates the GLP-1 receptor and inspired the drug exenatide.

Tirzepatide is an engineered dual glucose-dependent insulinotropic polypeptide (GIP) and GLP-1 receptor agonist peptide. It is an approved p…

Retatrutide is an investigational triple agonist peptide targeting GLP-1, GIP, and glucagon receptors. It is widely discussed in metabolic r…

AOD-9604 is a synthetic peptide related to the C-terminal region of human growth hormone, studied in metabolic and lipolysis-related researc…

Cagrilintide is a long-acting amylin analog peptide investigated for metabolic disease, often discussed alongside GLP-1 and dual/triple agon…

Survodutide (BI 456906) is an investigational dual GLP-1 and glucagon receptor agonist studied in metabolic and liver research. Unlike many …

Mazdutide (IBI362, LY3305677) is a dual GLP-1 and glucagon receptor agonist derived from oxyntomodulin. It has been studied in metabolic res…

Adipotide (Prohibitin-TP01) is an experimental chimeric peptidomimetic that pairs a homing sequence targeting adipose-tissue blood vessels w…

Liraglutide is a modified glucagon-like peptide-1 (GLP-1) analog carrying a fatty-acid chain that extends its circulation time. It is a pres…

Dulaglutide is a GLP-1 receptor agonist in which two modified GLP-1 peptide chains are fused to a human immunoglobulin (IgG4) Fc fragment. T…

Setmelanotide is a synthetic cyclic octapeptide that selectively activates the melanocortin-4 receptor (MC4R), a signaling hub in the brain'…

Pramlintide is a synthetic analog of the pancreatic hormone amylin, designed with proline substitutions so it stays soluble rather than aggr…

Amylin, or islet amyloid polypeptide (IAPP), is a 37-residue peptide hormone co-secreted with insulin from pancreatic beta cells. It is stud…

Glucagon is a 29-amino-acid peptide hormone from pancreatic alpha cells that raises blood glucose, opposing insulin. It is the archetypal co…

Oxyntomodulin is a 37-amino-acid gut hormone released from intestinal L-cells after eating. Because it activates both the GLP-1 and glucagon…

GIP (glucose-dependent insulinotropic polypeptide) is a 42-amino-acid incretin hormone released from intestinal K-cells after meals, where i…

Secretin is a 27-amino-acid hormone released from duodenal S-cells in response to stomach acid entering the small intestine. Discovered by B…

Motilin is a 22-amino-acid gut hormone secreted by endocrine cells of the small intestine. It coordinates the migrating motor complex, the w…

Peptide YY (PYY) is a 36-amino-acid gut hormone released from intestinal L-cells after eating, where it contributes to satiety and slows gas…

Obestatin is a 23-amino-acid peptide cleaved from the same preproghrelin precursor that produces ghrelin. It was originally proposed to oppo…

Nesfatin-1 is a peptide cleaved from the precursor protein nucleobindin-2 (NUCB2), produced in the hypothalamus and in peripheral tissues. I…

Cholecystokinin (CCK) is a peptide hormone and neurotransmitter released from intestinal I-cells and also produced widely in the brain. It t…

Gastrin is a peptide hormone released by G-cells of the gastric antrum that stimulates acid secretion from the stomach's parietal cells. Cir…

Lixisenatide is a synthetic GLP-1 receptor agonist built on the exendin-4 scaffold rather than on human GLP-1. Marketed as Lyxumia and Adlyx…

Albiglutide is a GLP-1 receptor agonist created by genetically fusing two modified GLP-1 sequences to human serum albumin, giving it a long …

Efpeglenatide is a long-acting GLP-1 receptor agonist built from an exendin-based peptide conjugated to an antibody Fc fragment for extended…

Teduglutide is a synthetic 33-amino-acid analog of glucagon-like peptide-2 (GLP-2). A single alanine-to-glycine substitution extends its hal…

Linaclotide is a synthetic 14-amino-acid peptide that activates guanylate cyclase-C on the intestinal lining, raising cyclic GMP and driving…

Plecanatide is a synthetic 16-amino-acid analog of the human peptide uroguanylin that activates intestinal guanylate cyclase-C. Increased cy…

Apelin is an endogenous peptide hormone processed from a 77-amino-acid precursor into active fragments such as apelin-13 and apelin-36. It i…

Adropin is a secreted peptide encoded by the energy homeostasis-associated gene (ENHO) and first described in 2008. Its 76-residue sequence …

Spexin (neuropeptide Q) is a 14-amino-acid endogenous peptide discovered by bioinformatic analysis in 2007. It signals through galanin recep…

Glucagon-like peptide-2 (GLP-2) is a 33-amino-acid gut hormone produced from proglucagon in intestinal L cells and co-released with GLP-1. A…

Uroguanylin is a 16-amino-acid peptide secreted by enterochromaffin cells of the duodenum and encoded by GUCA2B. As an endogenous guanylate …

Cotadutide (MEDI0382) is a synthetic peptide engineered as a balanced dual agonist of the GLP-1 and glucagon receptors. It is an investigati…

Pemvidutide (ALT-801) is an investigational dual GLP-1/glucagon receptor agonist developed by Altimmune and studied in clinical trials for o…

Efinopegdutide (MK-6024) is an investigational dual GLP-1/glucagon receptor co-agonist studied by Merck, more recently focused on non-alcoho…

Beinaglutide is a recombinant human GLP-1(7-36) that shares 100% sequence identity with native human GLP-1. Approved in China for type 2 dia…