Page data last changed: . Chemistry registry snapshot: . Registry refreshes and identity assessments are separate from scientific content review.
An experimental vasculature-targeting peptidomimetic studied in obesity models.
Also known as: Prohibitin-TP01 · TP01 · FTPP
Part of the Metabolic & GLP-1 peptides cluster
Overview
Adipotide (Prohibitin-TP01) is an experimental chimeric peptidomimetic that pairs a homing sequence targeting adipose-tissue blood vessels with a pro-apoptotic motif. Studied in animal obesity models, its clinical development was discontinued. It is not an approved therapeutic in Canada.
Source & context
Biological / chemical source: Synthetic peptidomimetic combining a homing sequence with a pro-apoptotic motif
Primary research or clinical context: Discontinued investigational compound; not an approved drug in Canada
Targeting design
Adipotide is built as a chimeric molecule: a peptide that homes to prohibitin and ANXA2 on the blood vessels feeding white adipose tissue, fused to a KLAKLAK-type sequence intended to disrupt mitochondrial membranes. The concept was to reduce fat depots by targeting their vascular supply.
Research findings and limits
Published work reported rapid weight loss in mouse and non-human-primate models, generating substantial interest. However, development was discontinued, and human efficacy and safety were not established. Search popularity outpaces the strength of clinical evidence for this compound.
Structure & chemistry
Molecular identity & reference confidence
Source-supported reference
Reference values are taken from the cited molecular record or curated profile. A database match is not independent laboratory verification; modifications, counter-ions, and formulations can change the measured mass.
- Molecular form
- Adipotide (source record; form not independently established)
- Species
- Not established by this molecular identity audit
- Termini (N / C)
- Not specified / Not specified
Average reference mass
Reference policy updated: 2026-10-05
- PubChem molecular record · 2026-10-01
- Molecular formula
- C111H206N36O28S2
- Average reference mass
- ≈ 2,557.2
- PubChem CID: 163360068
- CAS RN: 859216-15-2
Chemistry values: PubChem · fetched 2026-10-01.
Adipotide — reconstitution calculator
Enter how much peptide is in the vial and how much diluent (e.g. bacteriostatic water) is added. The tool returns the resulting solution concentration — and, for any amount you type, the volume it corresponds to. This is educational arithmetic, not a dosing recommendation.
Reference form: Adipotide (source record; form not independently established)Average reference mass: 2,557.2 Da
Enter an amount to see the volume it corresponds to.
Educational concentration mathematics only. This tool does not recommend a dose, amount, or protocol, and nothing here is medical advice. Many peptides are not authorized by Health Canada for human use — see our reconstitution and bacteriostatic-water guides for context.
FAQ about Adipotide
What is Adipotide?+
Adipotide (Prohibitin-TP01) is an experimental chimeric peptidomimetic that pairs a homing sequence targeting adipose-tissue blood vessels with a pro-apoptotic motif. Studied in animal obesity models, its clinical development was discontinued. It is not an approved therapeutic in Canada.
What Canadian product status is recorded for Adipotide?+
Canadian product status for Adipotide has not been verified in this profile. No verified record here does not mean no authorization exists. Status depends on the product, formulation and use; consult Health Canada's product records.
What is the typical length of Adipotide?+
Adipotide is not a classic amino-acid chain peptide in the same sense; see the profile for classification details.