A GLP-2 analog that promotes intestinal mucosal growth in short bowel syndrome.
Also known as: Gattex · Revestive
Part of the Metabolic & GLP-1 peptides cluster
Overview
Teduglutide is a synthetic 33-amino-acid analog of glucagon-like peptide-2 (GLP-2). A single alanine-to-glycine substitution extends its half-life from minutes to hours, and it is an approved therapeutic for short bowel syndrome, where it promotes intestinal mucosal growth. This page is educational and not medical advice.
Source & context
Biological / chemical source: Synthetic 33-amino-acid analog of GLP-2
Primary research or clinical context: Approved for short bowel syndrome
One-residue redesign
Native GLP-2 is degraded almost immediately by dipeptidyl peptidase-4. Replacing the second-position alanine with glycine blocks that cleavage, stretching the half-life to roughly two hours. It is a clean illustration of how a single amino-acid swap rescues a peptide from rapid inactivation.
Intestinal trophic action
By activating GLP-2 receptors in the gut, teduglutide increases villus height and mucosal surface area, improving fluid and nutrient absorption. In short bowel syndrome this can reduce dependence on parenteral nutrition, an outcome studied in its registration trials.
FAQ about Teduglutide
What is Teduglutide?+
Teduglutide is a synthetic 33-amino-acid analog of glucagon-like peptide-2 (GLP-2). A single alanine-to-glycine substitution extends its half-life from minutes to hours, and it is an approved therapeutic for short bowel syndrome, where it promotes intestinal mucosal growth. This page is educational and not medical advice.
Is Teduglutide an approved medicine?+
Teduglutide: Approved for short bowel syndrome. Always follow licensed medical guidance for approved products.
What is the typical length of Teduglutide?+
Teduglutide is commonly described as approximately 33 amino acids (GLP-2 analog).