Page data last changed: . Chemistry registry snapshot: . Registry refreshes and identity assessments are separate from scientific content review.
The master driver of stomach-acid secretion — and a shared receptor with CCK.
Also known as: gastrin-17 · gastrin-34
Part of the Metabolic & GLP-1 peptides cluster
Overview
Gastrin is a peptide hormone released by G-cells of the gastric antrum that stimulates acid secretion from the stomach's parietal cells. Circulating in several lengths such as gastrin-17 and gastrin-34, it is a foundational hormone in digestive physiology and in the study of acid-related disorders.
Source & context
Biological / chemical source: G-cells of the stomach antrum and duodenum
Primary research or clinical context: Endogenous hormone; central to acid-physiology and Zollinger–Ellison research
Structure and the CCK connection
Gastrin and cholecystokinin share the same C-terminal amidated pentapeptide, so they can act on overlapping receptors — gastrin works mainly through the CCK-B (CCK-2) receptor. The mature hormone also carries a sulfated tyrosine and circulates as multiple processed forms, illustrating peptide-family relatedness through shared motifs.
Physiology and clinical relevance
By driving parietal-cell acid output and mucosal growth, gastrin sits at the center of digestive physiology. Excess gastrin, as in gastrinoma (Zollinger–Ellison syndrome), is a classic teaching example. Coverage here is educational and describes hormone biology rather than diagnosis or treatment.
Structure & chemistry
Molecular identity & reference confidence
Source-supported reference
Reference values are taken from the cited molecular record or curated profile. A database match is not independent laboratory verification; modifications, counter-ions, and formulations can change the measured mass.
- Molecular form
- Gastrin (source record; form not independently established)
- Species
- Not established by this molecular identity audit
- Termini (N / C)
- Not specified / Not specified
Average reference mass
Reference policy updated: 2026-10-05
- IUPHAR/BPS source snapshot · 2026-10-01
- PubChem molecular record · 2026-10-01
- Molecular formula
- C97H126N20O32S
- Average reference mass
- ≈ 2,116.2
Chemistry values: PubChem, IUPHAR/BPS Guide to Pharmacology · fetched 2026-10-01.
Clinical development snapshot
ClinicalTrials.gov lists 61 registered studies with “Gastrin” as an intervention (snapshot 2026-10-01). A registry footprint is not evidence of efficacy or approval.
| NCT | Title | Phase | Status | Updated |
|---|---|---|---|---|
| NCT06379217 | NEPC Study: An Exploratory Safety and Efficacy Study With PSMA, SSTR2 and GRPR Targeted Radioligand Therapy in | Phase 1 | active not recruiting | 2026-09-22 |
| NCT07828678 | PET/CT Imaging of GRPR Expression in Various Tumors | Early phase 1 | not yet recruiting | 2026-09-18 |
| NCT05870579 | [177Lu]Lu-NeoB in Combination With Ribociclib and Fulvestrant in Participants With ER+, HER2- and GRPR+ Advanc | Phase 1 | active not recruiting | 2026-09-11 |
| NCT06247995 | A Phase I/II, Dose Finding and Optimization Study of [177Lu]Lu-NeoB in Combination With Capecitabine in Patien | Phase 2 | active not recruiting | 2026-09-11 |
| NCT00702533 | A New Method for Determining Gastric Acid Output Using a Wireless Capsule | — | completed | 2026-08-31 |
| NCT05889728 | Pilot Trial to Assess 68Ga Bombesin PET/CT (NeoB) Imaging for Staging of Breast Cancer | Phase 2 | completed | 2026-08-19 |
Gastrin — reconstitution calculator
Enter how much peptide is in the vial and how much diluent (e.g. bacteriostatic water) is added. The tool returns the resulting solution concentration — and, for any amount you type, the volume it corresponds to. This is educational arithmetic, not a dosing recommendation.
Reference form: Gastrin (source record; form not independently established)Average reference mass: 2,116.2 Da
Enter an amount to see the volume it corresponds to.
Educational concentration mathematics only. This tool does not recommend a dose, amount, or protocol, and nothing here is medical advice. Many peptides are not authorized by Health Canada for human use — see our reconstitution and bacteriostatic-water guides for context.
Change log
Dated observations from the data pipeline (registry flags, trial footprints, identifiers) and editorial reviews of this profile.
- Trials1 registered study added on ClinicalTrials.gov (now 61).
FAQ about Gastrin
What is Gastrin?+
Gastrin is a peptide hormone released by G-cells of the gastric antrum that stimulates acid secretion from the stomach's parietal cells. Circulating in several lengths such as gastrin-17 and gastrin-34, it is a foundational hormone in digestive physiology and in the study of acid-related disorders.
What Canadian product status is recorded for Gastrin?+
Canadian product status for Gastrin has not been verified in this profile. No verified record here does not mean no authorization exists. Status depends on the product, formulation and use; consult Health Canada's product records.
What is the typical length of Gastrin?+
Gastrin is not a classic amino-acid chain peptide in the same sense; see the profile for classification details.
Related peptides
References & further reading
- 1.Gemelli et al. (1987). Gastrin 17 and gastrin 34, before and after a meal, in newborn infants. J Pediatr Gastroenterol Nutr
- 2.Xiang et al. (2025). Evaluation of Pepsinogen I, II, Gastrin 17 and Helicobacter pylori IgG in Atrophic Gastritis: A Head-To-Head Comparison of Lateral Flow and Enzyme-Linked Immunosorbent Assays. Helicobacter
- 3.Rehfeld et al. (2007). The biology of cholecystokinin and gastrin peptides. Curr Top Med Chem
- 4.Rehfeld et al. (1976). The heterogeneity of gastrin, with reference to conversion of gastrin-17. Clin Endocrinol (Oxf)
- 5.Huang et al. (1989). Importance of sulfation of gastrin or cholecystokinin (CCK) on affinity for gastrin and CCK receptors. Peptides
- 6.Chen et al. (2000). Glycine-extended gastrin synergizes with gastrin 17 to stimulate acid secretion in gastrin-deficient mice. Gastroenterology
- 7.Copps et al. (2009). The production and role of gastrin-17 and gastrin-17-gly in gastrointestinal cancers. Protein Pept Lett
- 8.Lee et al. (2025). A Prospective Study on the Detection of Gastric Neoplasms Using Pepsinogen and Gastrin-17 Levels. Gut Liver
- 9.PubChem — compound summary for Gastrin (CID 44288444)
- 10.Wikipedia — Gastrin