Research peptide

MOTS-c

MOTS-c is a 16-amino-acid mitochondrial-derived peptide studied in metabolic stress and exercise-related experimental models.

By The Peptides Codex Editorial TeamReviewed July 10, 2026

Length

16 aa

Class

Research peptide

Function

Mitochondrial-derived peptide studied in metabolism models

Context

Research compound

Part of the emerging mitochondrial peptide research field.

Also known as: MOTS c · mitochondrial ORF peptide

Part of the Metabolic & GLP-1 peptides cluster

Overview

MOTS-c is a 16-amino-acid mitochondrial-derived peptide studied in metabolic stress and exercise-related experimental models.

Source & context

Biological / chemical source: Encoded by mitochondrial DNA (MT-RNR1 region)

Primary research or clinical context: Research compound

Mitochondrial peptides

Unlike most nuclear-encoded peptides, MOTS-c originates from a short open reading frame in mitochondrial DNA — a distinctive chapter in peptide biology.

FAQ about MOTS-c

What is MOTS-c?+

MOTS-c is a 16-amino-acid mitochondrial-derived peptide studied in metabolic stress and exercise-related experimental models.

Is MOTS-c an approved medicine?+

MOTS-c is discussed here as a research / educational topic. Research compound. This is not medical advice.

What is the typical length of MOTS-c?+

MOTS-c is commonly described as approximately 16 amino acids (Research peptide).

Related peptides

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Hormone

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BPC-157

Research peptide

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TB-500

Research peptide

TB-500 refers to a synthetic peptide fragment associated with thymosin beta-4 research, studied for effects on cell migration and tissue remodeling in experimental models. It is not an approved medicine.

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Research peptide

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References & further reading

Disclaimer: Educational content only. Not medical advice. Not instructions for human use. Research peptides and unapproved products may be restricted or illegal to market for human consumption in your jurisdiction. Consult qualified professionals and applicable law.

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Cite this: Peptides Codex — MOTS-c educational profile.

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