Page data last changed: . Chemistry registry snapshot: . Registry refreshes and identity assessments are separate from scientific content review.
Sister nonapeptide to oxytocin; differs by two residues.
Also known as: ADH · arginine vasopressin
Part of the Foundational & therapeutic peptides cluster
Overview
Vasopressin (antidiuretic hormone) is a nine-residue peptide closely related to oxytocin, central to water balance physiology.
Source & context
Biological / chemical source: Hypothalamus
Primary research or clinical context: Diabetes insipidus and related clinical uses
Comparison with oxytocin
Two residue differences dramatically shift receptor preference and physiology — a textbook example of sequence–function relationships in peptides.
Sequence
One-letter sequence commonly cited for Vasopressin (educational; isoforms and modifications may differ):
CYFQNCPRG
Residues plotted ~100° apart around an α-helix — clustering of one color reveals an amphipathic face.
Structure & chemistry
Molecular identity & reference confidence
Source-supported reference
Reference values are taken from the cited molecular record or curated profile. A database match is not independent laboratory verification; modifications, counter-ions, and formulations can change the measured mass.
- Molecular form
- Vasopressin (source record; form not independently established)
- Species
- Not established by this molecular identity audit
- Termini (N / C)
- Not specified / Not specified
Average reference mass
Reference policy updated: 2026-10-05
- IUPHAR/BPS source snapshot · 2026-10-01
- PubChem molecular record · 2026-10-01
- Molecular formula
- C46H65N15O12S2
- Average reference mass
- ≈ 1,084.2
- Status
- Approved medicine in at least one jurisdiction (IUPHAR record)
- PubChem CID: 644077
- IUPHAR ligand: 2168
- ChEMBL: CHEMBL373742
- DrugBank: DB00067
- CAS RN: 50-56-6
- UNII: Y4907O6MFD
Chemistry values: PubChem, IUPHAR/BPS Guide to Pharmacology · fetched 2026-10-01.
Clinical development snapshot
ClinicalTrials.gov lists 433 registered studies with “Vasopressin” as an intervention (snapshot 2026-10-01). A registry footprint is not evidence of efficacy or approval.
| NCT | Title | Phase | Status | Updated |
|---|---|---|---|---|
| NCT05958342 | CAlcium and VAsopressin Following Injury Early Resuscitation (CAVALIER) Trial | Phase 2 | recruiting | 2026-09-29 |
| NCT07840313 | Prophylactic Desmopressin Before Native Kidney Biopsy in Severe Renal Impairment | Not applicable | completed | 2026-09-25 |
| NCT07838493 | Oromucosal Oxytocin and Vasopressin Modulation of Emotional Face Attention | Not applicable | recruiting | 2026-09-24 |
| NCT07832032 | Biological Profiles of Neuropeptides, Neurotrophins and miRNA in Migraine | — | not yet recruiting | 2026-09-21 |
| NCT02742974 | Fluid Resuscitation Optimization in Surgical Trauma Patients (FROST) | Not applicable | terminated | 2026-09-09 |
| NCT04501861 | Hemodynamic Effect of Norepinephrine Versus Vasopressin on the Pulmonary Circulation in Cardiac Surgery Patien | Phase 3 | completed | 2026-09-01 |
Vasopressin — reconstitution calculator
Enter how much peptide is in the vial and how much diluent (e.g. bacteriostatic water) is added. The tool returns the resulting solution concentration — and, for any amount you type, the volume it corresponds to. This is educational arithmetic, not a dosing recommendation.
Reference form: Vasopressin (source record; form not independently established)Average reference mass: 1,084.2 Da
Enter an amount to see the volume it corresponds to.
Educational concentration mathematics only. This tool does not recommend a dose, amount, or protocol, and nothing here is medical advice. Many peptides are not authorized by Health Canada for human use — see our reconstitution and bacteriostatic-water guides for context.
Change log
Dated observations from the data pipeline (registry flags, trial footprints, identifiers) and editorial reviews of this profile.
- Trials4 registered studies added on ClinicalTrials.gov (now 433).
FAQ about Vasopressin
What is Vasopressin?+
Vasopressin (antidiuretic hormone) is a nine-residue peptide closely related to oxytocin, central to water balance physiology.
What Canadian product status is recorded for Vasopressin?+
Canadian product status for Vasopressin has not been verified in this profile. No verified record here does not mean no authorization exists. Status depends on the product, formulation and use; consult Health Canada's product records.
What is the typical length of Vasopressin?+
Vasopressin is commonly described as approximately 9 amino acids (Hormone).
Related peptides
References & further reading
- 1.Pearlstein et al. (2025). Management of Arginine Vasopressin Deficiency (Central Diabetes Insipidus) in Neonates and Infants. Horm Res Paediatr
- 2.Newell-Price (2023). Testing for Arginine Vasopressin Deficiency. N Engl J Med
- 3.Luppino et al. (2024). Propofol-induced transient arginine vasopressin deficiency. Endocrinol Diabetes Metab Case Rep
- 4.Marcinkowska et al. (2022). Arginine Vasopressin, Synaptic Plasticity, and Brain Networks. Curr Neuropharmacol
- 5.Ishikawa (2014). Arginine vasopressin in heart failure. Circ J
- 6.Dinh et al. (2021). Estrogen: reducing the pressure by arginine vasopressin. Cardiovasc Res
- 7.Oiso (2005). [Arginine vasopressin]. Nihon Rinsho
- 8.Yoshimura et al. (2021). Arginine vasopressin: Direct and indirect action on metabolism. Peptides
- 9.PubChem — compound summary for Argipressin / Arginine vasopressin (CID 644077)
- 10.Wikipedia — Vasopressin