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Antimicrobial

Defensin (HNP-1)

Human neutrophil peptide-1 (HNP-1) is an alpha-defensin antimicrobial peptide with a disulfide-stabilized structure important in innate immunity research.

By The Peptides Codex Editorial TeamReviewed July 10, 2026
Length
30 aa
Class
Antimicrobial
Function
Immune defense
Context
Infection research

Cationic AMP with a characteristic disulfide-stabilized fold.

Part of the Foundational & therapeutic peptides cluster

Overview

Human neutrophil peptide-1 (HNP-1) is an alpha-defensin antimicrobial peptide with a disulfide-stabilized structure important in innate immunity research.

Source & context

Biological / chemical source: Neutrophils

Primary research or clinical context: Infection research

Antimicrobial peptides

Defensins illustrate how peptide charge, amphipathicity, and disulfide frameworks enable membrane-active host defense — a major AMP research theme.

Sequence

One-letter sequence commonly cited for Defensin (HNP-1) (educational; isoforms and modifications may differ):

ACYCRIPACIAGERRYGTCIYQGRLWAFCC

ACYCRIPACIAGERRYGTCIYQGRLWAFCC

Analyze sequences in the playground →

FAQ about Defensin (HNP-1)

What is Defensin (HNP-1)?+

Human neutrophil peptide-1 (HNP-1) is an alpha-defensin antimicrobial peptide with a disulfide-stabilized structure important in innate immunity research.

Is Defensin (HNP-1) an approved medicine?+

Defensin (HNP-1) is discussed here as a research / educational topic. Infection research. This is not medical advice.

What is the typical length of Defensin (HNP-1)?+

Defensin (HNP-1) is commonly described as approximately 30 amino acids (Antimicrobial).

Related peptides

References & further reading

  1. 1.Wikipedia — Alpha defensin
  2. 2.PubChem — compound summary for Human Defensin NP-1 / HNP-1 (CID 16130476)
Disclaimer: Educational content only. Not medical advice. Not instructions for human use. Research peptides and unapproved products may be restricted or illegal to market for human consumption in your jurisdiction. Consult qualified professionals and applicable law.
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Cite this: Peptides Codex — Defensin (HNP-1) educational profile.
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