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Neuropeptide

Substance P

Substance P is an 11-amino-acid neuropeptide of the tachykinin family involved in pain signaling and neurogenic inflammation research.

By The Peptides Codex Editorial TeamReviewed July 10, 2026
Length
11 aa
Class
Neuropeptide
Function
Pain transmission
Context
Pain research

Tachykinin family peptide — central to nociception research.

Part of the Neuropeptides & signaling cluster

Overview

Substance P is an 11-amino-acid neuropeptide of the tachykinin family involved in pain signaling and neurogenic inflammation research.

Source & context

Biological / chemical source: Nervous system

Primary research or clinical context: Pain research

Sequence motif

The C-terminal FXGLM-amide motif is characteristic of tachykinins and important for receptor interaction at NK1 and related receptors.

Sequence

One-letter sequence commonly cited for Substance P (educational; isoforms and modifications may differ):

FAQ about Substance P

What is Substance P?+

Substance P is an 11-amino-acid neuropeptide of the tachykinin family involved in pain signaling and neurogenic inflammation research.

Is Substance P an approved medicine?+

Substance P is discussed here as a research / educational topic. Pain research. This is not medical advice.

What is the typical length of Substance P?+

Substance P is commonly described as approximately 11 amino acids (Neuropeptide).

Related peptides

References & further reading

  1. 1.Wikipedia — Substance P
  2. 2.PubChem — compound summary for Substance P (CID 36511)
Disclaimer: Educational content only. Not medical advice. Not instructions for human use. Research peptides and unapproved products may be restricted or illegal to market for human consumption in your jurisdiction. Consult qualified professionals and applicable law.
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Cite this: Peptides Codex — Substance P educational profile.
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