Tachykinin family peptide — central to nociception research.
Part of the Neuropeptides & signaling cluster
Overview
Substance P is an 11-amino-acid neuropeptide of the tachykinin family involved in pain signaling and neurogenic inflammation research.
Source & context
Biological / chemical source: Nervous system
Primary research or clinical context: Pain research
Sequence motif
The C-terminal FXGLM-amide motif is characteristic of tachykinins and important for receptor interaction at NK1 and related receptors.
Sequence
One-letter sequence commonly cited for Substance P (educational; isoforms and modifications may differ):
RPKPQQFFGLM
Residues plotted ~100° apart around an α-helix — clustering of one color reveals an amphipathic face.
FAQ about Substance P
What is Substance P?+
Substance P is an 11-amino-acid neuropeptide of the tachykinin family involved in pain signaling and neurogenic inflammation research.
Is Substance P an approved medicine?+
Substance P is discussed here as a research / educational topic. Pain research. This is not medical advice.
What is the typical length of Substance P?+
Substance P is commonly described as approximately 11 amino acids (Neuropeptide).