Long-acting GnRH agonist — chronic dosing downregulates pituitary receptors and suppresses sex hormones.
Also known as: Decapeptyl · GnRH agonist
Part of the Foundational & therapeutic peptides cluster
Overview
Triptorelin is a synthetic decapeptide analog of gonadotropin-releasing hormone (GnRH) and a long-acting agonist at the GnRH receptor. It is an approved prescription medicine used in prostate cancer, endometriosis, uterine fibroids, and central precocious puberty. This page is educational and is not medical advice.
Source & context
Biological / chemical source: Synthetic decapeptide analog of GnRH
Primary research or clinical context: Approved medicine for prostate cancer, endometriosis, uterine fibroids, and central precocious puberty (prescription)
Agonist paradox
A GnRH agonist first stimulates luteinizing hormone and follicle-stimulating hormone release, then, with sustained exposure, downregulates and desensitizes pituitary receptors. The net effect after the initial flare is reduced sex-hormone output, which underlies its clinical uses.
Structure
Triptorelin substitutes D-tryptophan at position 6 of the native GnRH decapeptide. This single change resists enzymatic breakdown and greatly extends activity, allowing depot formulations dosed weeks to months apart in approved products.
FAQ about Triptorelin
What is Triptorelin?+
Triptorelin is a synthetic decapeptide analog of gonadotropin-releasing hormone (GnRH) and a long-acting agonist at the GnRH receptor. It is an approved prescription medicine used in prostate cancer, endometriosis, uterine fibroids, and central precocious puberty. This page is educational and is not medical advice.
Is Triptorelin an approved medicine?+
Triptorelin: Approved medicine for prostate cancer, endometriosis, uterine fibroids, and central precocious puberty (prescription). Always follow licensed medical guidance for approved products.
What is the typical length of Triptorelin?+
Triptorelin is commonly described as approximately 10 amino acids (GnRH agonist (decapeptide analog)).