A first-in-class outer-membrane protein target: it binds LptD to block lipopolysaccharide transport in Pseudomonas.
Also known as: POL7080 · RG7929
Part of the Foundational & therapeutic peptides cluster
Overview
Murepavadin (POL7080) is a synthetic cyclic beta-hairpin peptidomimetic derived from the host-defense peptide protegrin I. Unlike broad membrane-lytic peptides, it is Pseudomonas-specific, binding the outer-membrane protein LptD to disrupt lipopolysaccharide transport, and it has been studied against multidrug-resistant Pseudomonas aeruginosa. This page is educational and not medical advice.
Source & context
Biological / chemical source: Synthetic cyclic beta-hairpin peptidomimetic based on protegrin I
Primary research or clinical context: Investigational antibiotic studied for Pseudomonas aeruginosa infections
Novel target
Murepavadin binds LptD, an outer-membrane protein essential for lipopolysaccharide biogenesis in Gram-negative bacteria. This mechanism differs from classic antibiotics and retains activity against many carbapenemase-producing and colistin-resistant Pseudomonas isolates, making it a notable research example of narrow-spectrum, target-specific peptidomimetics.
Development status
Intravenous murepavadin completed phase II studies and entered phase III for hospital-acquired and ventilator-associated pneumonia caused by Pseudomonas aeruginosa. Trials were affected by kidney-toxicity signals, and inhaled formulations have been explored. It is discussed here for scientific context, not as an approved therapy.
FAQ about Murepavadin
What is Murepavadin?+
Murepavadin (POL7080) is a synthetic cyclic beta-hairpin peptidomimetic derived from the host-defense peptide protegrin I. Unlike broad membrane-lytic peptides, it is Pseudomonas-specific, binding the outer-membrane protein LptD to disrupt lipopolysaccharide transport, and it has been studied against multidrug-resistant Pseudomonas aeruginosa. This page is educational and not medical advice.
Is Murepavadin an approved medicine?+
Murepavadin is discussed here as a research / educational topic. Investigational antibiotic studied for Pseudomonas aeruginosa infections. This is not medical advice.
What is the typical length of Murepavadin?+
Murepavadin is not a classic amino-acid chain peptide in the same sense; see the profile for classification details.