Amphibian peptide that defined the bombesin receptor family.
Part of the Neuropeptides & signaling cluster
Overview
Bombesin is a 14-amino-acid peptide first isolated from amphibian skin that gave its name to a family of mammalian receptors. It is widely used as a research tool in appetite and receptor-biology studies.
Source & context
Biological / chemical source: Originally isolated from frog (Bombina) skin
Primary research or clinical context: Neuroscience and receptor-imaging research
Receptor family it defined
Bombesin is the prototype for a receptor class whose mammalian members include the gastrin-releasing peptide receptor. Because these receptors are studied in tumor imaging, bombesin analogs appear frequently in radiopharmaceutical research literature.
Research-tool status
Bombesin is chiefly used as an experimental probe rather than a therapeutic. This page presents its receptor pharmacology for education and does not describe any human use.
Sequence
One-letter sequence commonly cited for Bombesin (educational; isoforms and modifications may differ):
EQRLGNQWAVGHLM
Residues plotted ~100° apart around an α-helix — clustering of one color reveals an amphipathic face.
FAQ about Bombesin
What is Bombesin?+
Bombesin is a 14-amino-acid peptide first isolated from amphibian skin that gave its name to a family of mammalian receptors. It is widely used as a research tool in appetite and receptor-biology studies.
Is Bombesin an approved medicine?+
Bombesin is discussed here as a research / educational topic. Neuroscience and receptor-imaging research. This is not medical advice.
What is the typical length of Bombesin?+
Bombesin is commonly described as approximately 14 amino acids (Neuropeptide).