Page data last changed: . Chemistry registry snapshot: . Registry refreshes and identity assessments are separate from scientific content review.
Cyclic non-ribosomal peptide — cornerstone of transplant medicine.
Part of the Foundational & therapeutic peptides cluster
Overview
Cyclosporin A is a cyclic non-ribosomal peptide immunosuppressant used in transplant medicine — a landmark natural product peptide drug.
Source & context
Biological / chemical source: Fungus (Tolypocladium)
Primary research or clinical context: Transplant medicine (approved)
Non-ribosomal synthesis
Unlike ribosomal peptides, cyclosporin is assembled by non-ribosomal peptide synthetases and includes non-proteinogenic residues — expanding what 'peptide drug' can mean.
Sequence
One-letter sequence commonly cited for Cyclosporin A (educational; isoforms and modifications may differ):
XXXLVLAALLV
X = non-canonical or modified residue in the IUPHAR record. X marks a non-canonical residue — see the structure block below. (Plotted as alanine on the wheel.)
Residues plotted ~100° apart around an α-helix — clustering of one color reveals an amphipathic face.
Structure & chemistry
Molecular identity & reference confidence
Source-supported reference
Reference values are taken from the cited molecular record or curated profile. A database match is not independent laboratory verification; modifications, counter-ions, and formulations can change the measured mass.
- Molecular form
- Cyclosporin A (source record; form not independently established)
- Species
- Not established by this molecular identity audit
- Termini (N / C)
- Not specified / Not specified
Average reference mass
Reference policy updated: 2026-10-05
- IUPHAR/BPS source snapshot · 2026-10-01
- PubChem molecular record · 2026-10-01
- Molecular formula
- C62H111N11O12
- Average reference mass
- ≈ 1,202.6
- Status
- Approved medicine in at least one jurisdiction (IUPHAR record)
- PubChem CID: 5284373
- IUPHAR ligand: 1024
- ChEMBL: CHEMBL160
- DrugBank: DB00091
- CAS RN: 59865-13-3
- UNII: 83HN0GTJ6D
Chemistry values: IUPHAR/BPS Guide to Pharmacology, PubChem · fetched 2026-10-01.
Clinical development snapshot
ClinicalTrials.gov lists 1,071 registered studies with “Cyclosporin A” as an intervention (snapshot 2026-10-01). A registry footprint is not evidence of efficacy or approval.
| NCT | Title | Phase | Status | Updated |
|---|---|---|---|---|
| NCT07290803 | This Study is a Non-interventional Disease Registry of Adolescent and Adult Patients With Atopic Dermatitis Wh | — | recruiting | 2026-09-29 |
| NCT03644667 | Tocilizumab in Cardiac Transplantation | Phase 2 | completed | 2026-09-29 |
| NCT06809608 | A Study Investigating the Effect of Different Approved Medications on How the Body Processes the Study Compoun | Phase 1 | completed | 2026-09-28 |
| NCT07843381 | Clinical Efficacy of Telitacicept in Sjögren's Disease With Interstitial Lung Disease | — | recruiting | 2026-09-28 |
| NCT05600426 | A Trial Comparing Unrelated Donor BMT With IST for Pediatric and Young Adult Patients With Severe Aplastic Ane | Phase 3 | active not recruiting | 2026-09-25 |
| NCT04018937 | Early Human Leukocyte Antigen (HLA) Matched Sibling Hematopoietic Stem Cell Transplantation | Phase 2 | active not recruiting | 2026-09-24 |
Cyclosporin A — reconstitution calculator
Enter how much peptide is in the vial and how much diluent (e.g. bacteriostatic water) is added. The tool returns the resulting solution concentration — and, for any amount you type, the volume it corresponds to. This is educational arithmetic, not a dosing recommendation.
Reference form: Cyclosporin A (source record; form not independently established)Average reference mass: 1,202.6 Da
Enter an amount to see the volume it corresponds to.
Educational concentration mathematics only. This tool does not recommend a dose, amount, or protocol, and nothing here is medical advice. Many peptides are not authorized by Health Canada for human use — see our reconstitution and bacteriostatic-water guides for context.
Change log
Dated observations from the data pipeline (registry flags, trial footprints, identifiers) and editorial reviews of this profile.
- Trials3 registered studies added on ClinicalTrials.gov (now 1071).
FAQ about Cyclosporin A
What is Cyclosporin A?+
Cyclosporin A is a cyclic non-ribosomal peptide immunosuppressant used in transplant medicine — a landmark natural product peptide drug.
What Canadian product status is recorded for Cyclosporin A?+
Canadian product status for Cyclosporin A has not been verified in this profile. No verified record here does not mean no authorization exists. Status depends on the product, formulation and use; consult Health Canada's product records.
What is the typical length of Cyclosporin A?+
Cyclosporin A is commonly described as approximately 11 amino acids (Cyclic).
Related peptides
References & further reading
- 1.Morris (1981). Cyclosporin A. Transplantation
- 2.Nussenblatt (1987). Cyclosporin A. Ann Inst Pasteur Immunol
- 3.Green (1979). Cyclosporin A. Lancet
- 4.Noda et al. (2019). Cyclosporin A: Teaching an Old Drug New Tricks?. Transplantation
- 5.Dieperink (1989). Cyclosporin A nephrotoxicity. Dan Med Bull
- 6.Lloveras Macià (1984). [Cyclosporin A]. Med Clin (Barc)
- 7.Thiele (1984). [Cyclosporin A]. Immun Infekt
- 8.Ross et al. (2008). Topical cyclosporin: a treatment for corneal graft rejection. Clin Exp Ophthalmol
- 9.PubChem — compound summary for Cyclosporin A (CID 5284373)
- 10.Wikipedia — Ciclosporin