Page data last changed: . Chemistry registry snapshot: . Registry refreshes and identity assessments are separate from scientific content review.
A two-residue peptide isolated from thymalin — the minimal fragment credited with much of its immune activity.
Also known as: glutamyl-tryptophan · L-Glu-L-Trp · thymagen
Part of the Neuropeptides & signaling cluster
Overview
Thymogen is a synthetic dipeptide, L-glutamyl-L-tryptophan (Glu-Trp), from the Khavinson family of short-peptide bioregulators. Identified as an active fragment of the thymic extract thymalin, it has been studied for effects on immune cell differentiation in Russian research. It is not authorized by Health Canada, and this page is educational only.
Source & context
Biological / chemical source: Synthetic dipeptide originally identified as an active fragment of the thymic preparation thymalin
Primary research or clinical context: Investigational bioregulator studied in Russian immunology and aging research; not authorized by Health Canada
A minimal bioregulator
Thymogen was obtained by isolating the active dipeptide Glu-Trp from the natural thymic preparation thymalin, then producing it synthetically. It is one of the smallest Khavinson peptides and is studied for reported effects on T-cell maturation and immune signalling. Its size makes it a striking example of the hypothesis that very short peptides can carry regulatory information.
Evidence and regulatory status
Reported studies, largely from Russian institutes, describe immunomodulatory and geroprotective effects in rodent models, with limited independent Western replication. Thymogen is investigational, sold for research use only in most markets, and is not authorized by Health Canada. This page is educational and makes no claim that it is safe, effective or therapeutic.
Structure & chemistry
Molecular identity & reference confidence
Source-supported reference
Reference values are taken from the cited molecular record or curated profile. A database match is not independent laboratory verification; modifications, counter-ions, and formulations can change the measured mass.
- Molecular form
- Thymogen (source record; form not independently established)
- Species
- Not established by this molecular identity audit
- Termini (N / C)
- Not specified / Not specified
Average reference mass
Reference policy updated: 2026-10-05
- PubChem molecular record · 2026-10-01
- Molecular formula
- C16H19N3O5
- Average reference mass
- ≈ 333.34
- PubChem CID: 100094
- CAS RN: 38101-59-6
- UNII: 4RHY598T5U
Chemistry values: PubChem · fetched 2026-10-01.
Thymogen — reconstitution calculator
Enter how much peptide is in the vial and how much diluent (e.g. bacteriostatic water) is added. The tool returns the resulting solution concentration — and, for any amount you type, the volume it corresponds to. This is educational arithmetic, not a dosing recommendation.
Reference form: Thymogen (source record; form not independently established)Average reference mass: 333.34 Da
Enter an amount to see the volume it corresponds to.
Educational concentration mathematics only. This tool does not recommend a dose, amount, or protocol, and nothing here is medical advice. Many peptides are not authorized by Health Canada for human use — see our reconstitution and bacteriostatic-water guides for context.
FAQ about Thymogen
What is Thymogen?+
Thymogen is a synthetic dipeptide, L-glutamyl-L-tryptophan (Glu-Trp), from the Khavinson family of short-peptide bioregulators. Identified as an active fragment of the thymic extract thymalin, it has been studied for effects on immune cell differentiation in Russian research. It is not authorized by Health Canada, and this page is educational only.
What Canadian product status is recorded for Thymogen?+
Canadian product status for Thymogen has not been verified in this profile. No verified record here does not mean no authorization exists. Status depends on the product, formulation and use; consult Health Canada's product records.
What is the typical length of Thymogen?+
Thymogen is commonly described as approximately 2 amino acids (Synthetic dipeptide immunomodulator (Khavinson class)).
Related peptides
References & further reading
- 1.Chulanova et al. (2023). Reparative and Antioxidant Effects of New Analogues of Immunomodulator Thymogen in Experimental Model of Liver Damage. Bull Exp Biol Med
- 2.Chulanova et al. (2025). Hepatoprotective Effects of Thymogen Analogues in Hydrazine Hepatopathy in Rats. Bull Exp Biol Med
- 3.Anisimov et al. (1992). [The effect of the synthetic immunomodulator thymogen on radiation-induced carcinogenesis in rats]. Vopr Onkol
- 4.Deigin et al. (2024). The First Reciprocal Activities of Chiral Peptide Pharmaceuticals: Thymogen and Thymodepressin, as Examples. Int J Mol Sci
- 5.Iushchuk et al. (1995). [The efficacy of using thymogen in an experimental infection caused by Yersinia enterocolitica]. Zh Mikrobiol Epidemiol Immunobiol
- 6.Zhuk et al. (1996). [Thymogen in the treatment of type-1 diabetes mellitus]. Ter Arkh
- 7.Zoloedov et al. (1995). [Treatment with thymogen and myelopid of patients with bronchial asthma]. Klin Med (Mosk)
- 8.Okovityĭ et al. (2002). [Immune mechanisms of hepatoprotector effects of etomersol and thymogen]. Eksp Klin Farmakol
- 9.Biogerontology — Immunomodulatory synthetic dipeptide L-Glu-L-Trp slows down aging and inhibits carcinogenesis in rats
- 10.PMC — Peptides as epigenetic modulators: therapeutic implications (Khavinson peptides review)