One of the largest AMP families — very short frog-skin peptides active mainly on Gram-positive microbes.
Also known as: temporin A · temporin B
Part of the Foundational & therapeutic peptides cluster
Overview
Temporins are a large family of short antimicrobial peptides first isolated from the European frog Rana temporaria. Members such as temporin A and temporin B are typically 10-14 residues, fold on microbial membranes, and are studied for activity against Gram-positive bacteria and fungi. They are research peptides, not approved drugs.
Source & context
Biological / chemical source: Skin secretions of frogs (originally Rana temporaria)
Primary research or clinical context: Antimicrobial-peptide research (not an approved drug)
A very short AMP family
Temporins are among the shortest natural antimicrobial peptides, with temporin A (FLPLIGRVLSGIL) a well-studied example. Their small size and low net charge make them useful models for how brief amphipathic sequences still disrupt microbial membranes.
Research directions
Literature explores temporin activity against Gram-positive bacteria, fungi and some protozoa, plus cooperative behavior where temporin B and temporin L form hetero-oligomers. These are investigational research peptides; no therapeutic use is implied here.
FAQ about Temporin
What is Temporin?+
Temporins are a large family of short antimicrobial peptides first isolated from the European frog Rana temporaria. Members such as temporin A and temporin B are typically 10-14 residues, fold on microbial membranes, and are studied for activity against Gram-positive bacteria and fungi. They are research peptides, not approved drugs.
Is Temporin an approved medicine?+
Temporin is discussed here as a research / educational topic. Antimicrobial-peptide research (not an approved drug). This is not medical advice.
What is the typical length of Temporin?+
Temporin is not a classic amino-acid chain peptide in the same sense; see the profile for classification details.