A GnRH decapeptide unusual for being delivered as a nasal spray.
Also known as: Synarel
Part of the Foundational & therapeutic peptides cluster
Overview
Nafarelin is a synthetic decapeptide GnRH agonist administered intranasally. Continuous receptor activation desensitizes the pituitary and suppresses luteinizing and follicle-stimulating hormone, and it is an approved therapeutic for endometriosis and central precocious puberty. This page is educational and not medical advice.
Source & context
Biological / chemical source: Synthetic decapeptide analog of GnRH
Primary research or clinical context: Approved for endometriosis and central precocious puberty (intranasal)
Intranasal delivery
Nafarelin's nasal-spray formulation is notable because most GnRH analogs require injection or implant. Nasal absorption offers a needle-free route, illustrating how peptide lipophilicity and potency can be tuned to enable mucosal delivery.
Hormone suppression
Repeated dosing collapses pituitary gonadotropin output, lowering estrogen and reducing endometriotic tissue activity or halting premature pubertal progression. Nafarelin is a well-studied member of the GnRH-analog class alongside leuprolide and goserelin.
FAQ about Nafarelin
What is Nafarelin?+
Nafarelin is a synthetic decapeptide GnRH agonist administered intranasally. Continuous receptor activation desensitizes the pituitary and suppresses luteinizing and follicle-stimulating hormone, and it is an approved therapeutic for endometriosis and central precocious puberty. This page is educational and not medical advice.
Is Nafarelin an approved medicine?+
Nafarelin: Approved for endometriosis and central precocious puberty (intranasal). Always follow licensed medical guidance for approved products.
What is the typical length of Nafarelin?+
Nafarelin is commonly described as approximately 10 amino acids (GnRH agonist).