The first mitochondria-derived peptide discovered — a hub of longevity research.
Also known as: HN · MT-RNR2-derived peptide
Part of the Neuropeptides & signaling cluster
Overview
Humanin is a mitochondrial-derived peptide encoded within the MT-RNR2 (16S rRNA) gene and was the first such peptide discovered. It is studied as a cytoprotective signaling molecule in aging and neuroprotection research. It is not an approved therapeutic in Canada.
Source & context
Biological / chemical source: Encoded within the mitochondrial 16S rRNA gene (MT-RNR2)
Primary research or clinical context: Research peptide; not an approved drug in Canada
A mitochondrial messenger
Humanin is encoded inside the mitochondrial genome and is the founding member of the mitochondria-derived peptide (MDP) family, alongside compounds like MOTS-c. The cytosolic form is 24 residues (MAPRGFSCLLLLTSEIDLPVKRRA), while a shorter mitochondrially translated variant is about 21 residues.
Research directions
Laboratory studies have examined humanin in the context of cellular stress responses, neuroprotection, and metabolic signaling, which is why it appears frequently in longevity discussions. Most evidence is preclinical; human clinical data remain limited, so claims should be interpreted carefully.
Why it is searched
Interest in mitochondrial peptides and aging biology has pushed humanin into popular longevity content. This page summarizes its biology for educational purposes and does not provide dosing, protocols, or therapeutic recommendations.
Sequence
One-letter sequence commonly cited for Humanin (educational; isoforms and modifications may differ):
FAQ about Humanin
What is Humanin?+
Humanin is a mitochondrial-derived peptide encoded within the MT-RNR2 (16S rRNA) gene and was the first such peptide discovered. It is studied as a cytoprotective signaling molecule in aging and neuroprotection research. It is not an approved therapeutic in Canada.
Is Humanin an approved medicine?+
Humanin is discussed here as a research / educational topic. Research peptide; not an approved drug in Canada. This is not medical advice.
What is the typical length of Humanin?+
Humanin is commonly described as approximately 24 amino acids (Mitochondrial-derived peptide (MDP)).