A GnRH decapeptide delivered as a subcutaneous depot implant.
Also known as: Zoladex
Part of the Foundational & therapeutic peptides cluster
Overview
Goserelin is a synthetic decapeptide GnRH agonist that suppresses gonadal sex-hormone production through non-pulsatile receptor stimulation. It is an approved therapeutic for hormone-responsive breast and prostate cancers and several benign gynecologic conditions. Content here is educational only.
Source & context
Biological / chemical source: Synthetic decapeptide analog of GnRH
Primary research or clinical context: Approved for breast and prostate cancer, endometriosis and assisted reproduction
Depot implant design
Goserelin is formulated as a biodegradable implant injected under the skin, releasing peptide slowly over one to three months. This delivery approach solves the short half-life problem common to peptide hormones and is a classic example of sustained-release peptide engineering.
Endocrine effect
By overriding the normal pulsatile GnRH rhythm, goserelin drives the pituitary into down-regulation, reducing testosterone in men and estrogen in women. It is studied and used across oncology, endometriosis, fibroids and fertility protocols.
FAQ about Goserelin
What is Goserelin?+
Goserelin is a synthetic decapeptide GnRH agonist that suppresses gonadal sex-hormone production through non-pulsatile receptor stimulation. It is an approved therapeutic for hormone-responsive breast and prostate cancers and several benign gynecologic conditions. Content here is educational only.
Is Goserelin an approved medicine?+
Goserelin: Approved for breast and prostate cancer, endometriosis and assisted reproduction. Always follow licensed medical guidance for approved products.
What is the typical length of Goserelin?+
Goserelin is commonly described as approximately 10 amino acids (GnRH agonist).