Endogenous opioid with high preference for kappa-opioid receptors.
Also known as: Dynorphin A
Part of the Neuropeptides & signaling cluster
Overview
Dynorphin is a family of endogenous opioid peptides (dynorphin A is 17 residues) derived from prodynorphin. It preferentially activates kappa-opioid receptors and is studied in stress and mood neurobiology.
Source & context
Biological / chemical source: Central nervous system; derived from prodynorphin
Primary research or clinical context: Neuroscience research
Kappa-opioid preference
Unlike endorphins, dynorphins act mainly at kappa-opioid receptors and are associated in research with dysphoric and stress-related signaling — a contrast that illustrates how opioid peptide subtypes differ in function.
Prodynorphin family
Prodynorphin is cleaved into several related peptides, including dynorphin A, dynorphin B, and the neoendorphins. This precursor biology is a common theme in opioid-peptide education.
Sequence
One-letter sequence commonly cited for Dynorphin (educational; isoforms and modifications may differ):
YGGFLRRIRPKLKWDNQ
Residues plotted ~100° apart around an α-helix — clustering of one color reveals an amphipathic face.
FAQ about Dynorphin
What is Dynorphin?+
Dynorphin is a family of endogenous opioid peptides (dynorphin A is 17 residues) derived from prodynorphin. It preferentially activates kappa-opioid receptors and is studied in stress and mood neurobiology.
Is Dynorphin an approved medicine?+
Dynorphin is discussed here as a research / educational topic. Neuroscience research. This is not medical advice.
What is the typical length of Dynorphin?+
Dynorphin is commonly described as approximately 17 amino acids (Neuropeptide).