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Neuropeptide

Met-enkephalin

Met-enkephalin (YGGFM) is an endogenous opioid pentapeptide foundational to pain and reward neurobiology research.

By The Peptides Codex Editorial TeamReviewed July 10, 2026
Length
5 aa
Class
Neuropeptide
Function
Opioid signaling, pain modulation
Context
Pain & reward research

Pentapeptide opioid — YGGF is the classic motif.

Part of the Neuropeptides & signaling cluster

Overview

Met-enkephalin (YGGFM) is an endogenous opioid pentapeptide foundational to pain and reward neurobiology research.

Source & context

Biological / chemical source: Brain, adrenal

Primary research or clinical context: Pain & reward research

Opioid peptide family

Enkephalins, endorphins, and dynorphins share related motifs and receptor preferences — a core chapter in neuropeptide education.

Sequence

One-letter sequence commonly cited for Met-enkephalin (educational; isoforms and modifications may differ):

FAQ about Met-enkephalin

What is Met-enkephalin?+

Met-enkephalin (YGGFM) is an endogenous opioid pentapeptide foundational to pain and reward neurobiology research.

Is Met-enkephalin an approved medicine?+

Met-enkephalin is discussed here as a research / educational topic. Pain & reward research. This is not medical advice.

What is the typical length of Met-enkephalin?+

Met-enkephalin is commonly described as approximately 5 amino acids (Neuropeptide).

Related peptides

References & further reading

  1. 1.Wikipedia — Met-enkephalin
  2. 2.PubChem — compound summary for Met-enkephalin (CID 443363)
Disclaimer: Educational content only. Not medical advice. Not instructions for human use. Research peptides and unapproved products may be restricted or illegal to market for human consumption in your jurisdiction. Consult qualified professionals and applicable law.
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Cite this: Peptides Codex — Met-enkephalin educational profile.
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