Page data last changed: . Registry refreshes and identity assessments are separate from scientific content review.
Short peptide fragments cut from collagen for easy dissolving and digestion.
Also known as: hydrolyzed collagen · collagen hydrolysate
Part of the Cosmetic & skin peptides cluster
Overview
Collagen peptides, also called hydrolyzed collagen or collagen hydrolysate, are a mixture of short peptides produced by breaking down animal collagen. They are rich in glycine, proline and hydroxyproline and dissolve readily in liquids. Sold as supplements and cosmetic ingredients, they are described here for education, not as medical advice.
Source & context
Biological / chemical source: Enzymatic or heat hydrolysis of animal collagen (skin, bone, fish)
Primary research or clinical context: Sold as a dietary supplement and cosmetic ingredient
What hydrolysis produces
Native collagen is a large triple-helix protein. Acid, alkaline or enzymatic hydrolysis cleaves it into a heterogeneous blend of peptides of varying length, which is why no single sequence or residue count defines collagen peptides. The mixture is dominated by the glycine-proline-hydroxyproline motifs characteristic of collagen.
Uses and status
Because the fragments are small and water-soluble, collagen peptides are added to drinks, powders and cosmetic formulations. They are regulated as foods or supplements rather than as drugs. This educational summary describes what collagen peptides are and how they are made, without claims about skin, joint or other health outcomes.
Structure & chemistry
Molecular identity & reference confidence
Reference mass unavailable
Reference values are taken from the cited molecular record or curated profile. A database match is not independent laboratory verification; modifications, counter-ions, and formulations can change the measured mass.
- Molecular form
- Collagen peptides (source record; form not independently established)
- Species
- Not established by this molecular identity audit
- Termini (N / C)
- Not specified / Not specified
Average reference mass
Reference policy updated: 2026-10-05
Clinical development snapshot
ClinicalTrials.gov lists 233 registered studies with “Collagen peptides” as an intervention (snapshot 2026-10-01). A registry footprint is not evidence of efficacy or approval.
| NCT | Title | Phase | Status | Updated |
|---|---|---|---|---|
| NCT07841106 | Early Prophylactic Versus Late Salvage Recombinant Human Endostatin in Managing Radiosurgery-Induced Brain Inj | Phase 2 | not yet recruiting | 2026-10-01 |
| NCT06787924 | Effect of a Preoperative Oral Collagen-Based Formulation on Dermal Collagen Content, Wound Outcomes, and Scar | Not applicable | completed | 2026-09-28 |
| NCT07572240 | A Clinical Trial to Assess the Effect of AP-Brain Collagen Peptides on the Improvement of Attention, Focus, an | Not applicable | active not recruiting | 2026-09-21 |
| NCT07827014 | An Open-Label, Two-Arm Pilot Study of the Tolerability, Consumer Acceptability, and Exploratory Well-Being Out | Not applicable | recruiting | 2026-09-18 |
| NCT07367165 | Effects of CGF and Collagen Fleece on Palatal Donor Site Healing: A Randomized Clinical Trial | Not applicable | completed | 2026-09-10 |
| NCT07654218 | Guided Bone Regeneration Combined With PRGF for Atrophic Edentulous Maxilla | Not applicable | completed | 2026-09-09 |
Change log
Dated observations from the data pipeline (registry flags, trial footprints, identifiers) and editorial reviews of this profile.
- Trials2 registered studies added on ClinicalTrials.gov (now 233).
FAQ about Collagen peptides
What is Collagen peptides?+
Collagen peptides, also called hydrolyzed collagen or collagen hydrolysate, are a mixture of short peptides produced by breaking down animal collagen. They are rich in glycine, proline and hydroxyproline and dissolve readily in liquids. Sold as supplements and cosmetic ingredients, they are described here for education, not as medical advice.
What Canadian product status is recorded for Collagen peptides?+
Canadian product status for Collagen peptides has not been verified in this profile. No verified record here does not mean no authorization exists. Status depends on the product, formulation and use; consult Health Canada's product records.
What is the typical length of Collagen peptides?+
Collagen peptides is not a classic amino-acid chain peptide in the same sense; see the profile for classification details.
Related peptides
References & further reading
- 1.Proksch et al. (2014). Oral supplementation of specific collagen peptides has beneficial effects on human skin physiology: a double-blind, placebo-controlled study. Skin Pharmacol Physiol
- 2.König et al. (2018). Specific Collagen Peptides Improve Bone Mineral Density and Bone Markers in Postmenopausal Women-A Randomized Controlled Study. Nutrients
- 3.Inacio et al. (2024). The Effects of Collagen Peptides as a Dietary Supplement on Muscle Damage Recovery and Fatigue Responses: An Integrative Review. Nutrients
- 4.Zdzieblik et al. (2017). Improvement of activity-related knee joint discomfort following supplementation of specific collagen peptides. Appl Physiol Nutr Metab
- 5.Yamada et al. (2021). Functional roles of fish collagen peptides on bone regeneration. Dent Mater J
- 6.Iwai et al. (2005). Identification of food-derived collagen peptides in human blood after oral ingestion of gelatin hydrolysates. J Agric Food Chem
- 7.Czajka et al. (2018). Daily oral supplementation with collagen peptides combined with vitamins and other bioactive compounds improves skin elasticity and has a beneficial effect on joint and general wellbeing. Nutr Res
- 8.Jiang et al. (2025). Collagen peptides from Skipjack tuna (Katsuwonus pelamis) bones: Composition, characterization, and mechanism of high-fat diet-induced NAFLD amelioration. Food Res Int
- 9.Wikipedia — Hydrolyzed collagen (collagen peptides)
- 10.Wikipedia — Collagen