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A rare peptide hormone that needs a bound zinc ion to fold and become active.
Also known as: zinc thymic factor · facteur thymique serique
Part of the Repair & recovery peptides cluster
Overview
Thymulin is a nonapeptide thymic hormone produced by thymic epithelial cells that requires a zinc ion for its biological activity and characteristic fold. It is studied for roles in T-cell differentiation and immune modulation. It is a research peptide and is not authorized by Health Canada for therapeutic use.
Source & context
Biological / chemical source: Thymic epithelial cells
Primary research or clinical context: Immunology research (not authorized by Health Canada)
Zinc dependence
Thymulin's defining feature is that it binds a Zn2+ ion to adopt its active three-dimensional structure; without zinc the peptide is biologically inactive. This zinc requirement makes it a notable example of a metal-dependent peptide hormone in immunology.
Immune-research role
Thymulin is studied for its influence on T-cell differentiation and natural-killer-cell activity, and can partially restore some T-cell functions in thymectomized animal models. Coverage here is educational and does not describe any approved therapeutic use.
Structure & chemistry
Molecular identity & reference confidence
Source-supported reference
Reference values are taken from the cited molecular record or curated profile. A database match is not independent laboratory verification; modifications, counter-ions, and formulations can change the measured mass.
- Molecular form
- Thymulin (source record; form not independently established)
- Species
- Not established by this molecular identity audit
- Termini (N / C)
- Not specified / Not specified
Average reference mass
Reference policy updated: 2026-10-05
- PubChem molecular record · 2026-10-01
- Molecular formula
- C33H54N12O15
- Average reference mass
- ≈ 858.9
- PubChem CID: 71300623
- CAS RN: 78922-62-0
Chemistry values: PubChem · fetched 2026-10-01.
Thymulin — reconstitution calculator
Enter how much peptide is in the vial and how much diluent (e.g. bacteriostatic water) is added. The tool returns the resulting solution concentration — and, for any amount you type, the volume it corresponds to. This is educational arithmetic, not a dosing recommendation.
Reference form: Thymulin (source record; form not independently established)Average reference mass: 858.9 Da
Enter an amount to see the volume it corresponds to.
Educational concentration mathematics only. This tool does not recommend a dose, amount, or protocol, and nothing here is medical advice. Many peptides are not authorized by Health Canada for human use — see our reconstitution and bacteriostatic-water guides for context.
FAQ about Thymulin
What is Thymulin?+
Thymulin is a nonapeptide thymic hormone produced by thymic epithelial cells that requires a zinc ion for its biological activity and characteristic fold. It is studied for roles in T-cell differentiation and immune modulation. It is a research peptide and is not authorized by Health Canada for therapeutic use.
What Canadian product status is recorded for Thymulin?+
Canadian product status for Thymulin has not been verified in this profile. No verified record here does not mean no authorization exists. Status depends on the product, formulation and use; consult Health Canada's product records.
What is the typical length of Thymulin?+
Thymulin is commonly described as approximately 9 amino acids (Immunomodulatory peptide).
Related peptides
References & further reading
- 1.Kanemaru et al. (2026). Thymulin restrains age-associated myeloid inflammation and enhances cancer immunotherapy. Nat Commun
- 2.Bach et al. (1989). Thymulin, a zinc-dependent hormone. Med Oncol Tumor Pharmacother
- 3.Jambon et al. (1988). Thymulin (facteur thymique serique) and zinc contents of the thymus glands of malnourished children. Am J Clin Nutr
- 4.Pleau et al. (1985). Thymulin. Methods Enzymol
- 5.Lunin et al. (2023). Protective effect of exogenous peroxiredoxin 6 and thymic peptide thymulin on BBB conditions in an experimental model of multiple sclerosis. Arch Biochem Biophys
- 6.Safieh-Garabedian et al. (2019). Targeting inflammatory components in neuropathic pain: The analgesic effect of thymulin related peptide. Neurosci Lett
- 7.Safieh-Garabedian et al. (1992). Thymulin and its role in immunomodulation. J Autoimmun
- 8.Dokhelar et al. (1983). Effect of a synthetic thymic factor (facteur thymique serique) on natural killer cell activity in humans. Int J Immunopharmacol
- 9.Wikipedia — Thymulin