Page data last changed: . Chemistry registry snapshot: . Registry refreshes and identity assessments are separate from scientific content review.
A compact cyclic hexapeptide that helped map somatostatin receptor subtype pharmacology.
Also known as: MK-678 · L-363,586 · somatostatin analog
Part of the Foundational & therapeutic peptides cluster
Overview
Seglitide (MK-678) is a synthetic cyclic hexapeptide analog of somatostatin with strong activity at the SSTR2 receptor subtype. It has been used as a research tool to study somatostatin receptor pharmacology and is not an approved medicine authorized by Health Canada. This page is educational and is not medical advice.
Source & context
Biological / chemical source: Synthetic cyclic hexapeptide analog of somatostatin
Primary research or clinical context: Investigational/research somatostatin analog; not an approved medicine and not authorized by Health Canada
Cyclic hexapeptide design
By condensing the essential binding residues of somatostatin into a small constrained ring, seglitide illustrates how medicinal chemists reduce a 14-residue hormone to a compact, more stable analog while retaining receptor activity.
Research role
Seglitide has been used experimentally to probe somatostatin receptor subtypes and downstream signaling, including inhibition of hormone secretion. Reported pharmacology can vary by tissue, making it a useful comparator in receptor studies.
Sequence
One-letter sequence commonly cited for Seglitide (educational; isoforms and modifications may differ):
AYWKVF
Residues plotted ~100° apart around an α-helix — clustering of one color reveals an amphipathic face.
Structure & chemistry
Molecular identity & reference confidence
Source-supported reference
Reference values are taken from the cited molecular record or curated profile. A database match is not independent laboratory verification; modifications, counter-ions, and formulations can change the measured mass.
- Molecular form
- Seglitide (source record; form not independently established)
- Species
- Not established by this molecular identity audit
- Termini (N / C)
- Not specified / Not specified
Average reference mass
Reference policy updated: 2026-10-05
- IUPHAR/BPS source snapshot · 2026-10-01
- PubChem molecular record · 2026-10-01
- Molecular formula
- C44H56N8O7
- Average reference mass
- ≈ 809
Alanine is N-methylated alanine, tryprophan is D-Trp
- PubChem CID: 5311430
- IUPHAR ligand: 2051
- ChEMBL: CHEMBL311695
- CAS RN: 81377-02-8
- UNII: 5P57R7IR6J
Chemistry values: IUPHAR/BPS Guide to Pharmacology, PubChem · fetched 2026-10-01.
Seglitide — reconstitution calculator
Enter how much peptide is in the vial and how much diluent (e.g. bacteriostatic water) is added. The tool returns the resulting solution concentration — and, for any amount you type, the volume it corresponds to. This is educational arithmetic, not a dosing recommendation.
Reference form: Seglitide (source record; form not independently established)Average reference mass: 809 Da
Enter an amount to see the volume it corresponds to.
Educational concentration mathematics only. This tool does not recommend a dose, amount, or protocol, and nothing here is medical advice. Many peptides are not authorized by Health Canada for human use — see our reconstitution and bacteriostatic-water guides for context.
FAQ about Seglitide
What is Seglitide?+
Seglitide (MK-678) is a synthetic cyclic hexapeptide analog of somatostatin with strong activity at the SSTR2 receptor subtype. It has been used as a research tool to study somatostatin receptor pharmacology and is not an approved medicine authorized by Health Canada. This page is educational and is not medical advice.
What Canadian product status is recorded for Seglitide?+
Canadian product status for Seglitide has not been verified in this profile. No verified record here does not mean no authorization exists. Status depends on the product, formulation and use; consult Health Canada's product records.
What is the typical length of Seglitide?+
Seglitide is commonly described as approximately 6 amino acids (Somatostatin analog (cyclic hexapeptide)).
Related peptides
References & further reading
- 1.Dimech et al. (1993). Antagonist effects of seglitide (MK 678) at somatostatin receptors in guinea-pig isolated right atria. Br J Pharmacol
- 2.Mitchell et al. (2000). Ventral subiculum administration of the somatostatin receptor agonist MK-678 increases dopamine levels in the nucleus accumbens. Eur J Pharmacol
- 3.PubChem — compound summary for Seglitide (CID 5311430)