A compact cyclic hexapeptide that helped map somatostatin receptor subtype pharmacology.
Also known as: MK-678 · L-363,586 · somatostatin analog
Part of the Foundational & therapeutic peptides cluster
Overview
Seglitide (MK-678) is a synthetic cyclic hexapeptide analog of somatostatin with strong activity at the SSTR2 receptor subtype. It has been used as a research tool to study somatostatin receptor pharmacology and is not an approved medicine authorized by Health Canada. This page is educational and is not medical advice.
Source & context
Biological / chemical source: Synthetic cyclic hexapeptide analog of somatostatin
Primary research or clinical context: Investigational/research somatostatin analog; not an approved medicine and not authorized by Health Canada
Cyclic hexapeptide design
By condensing the essential binding residues of somatostatin into a small constrained ring, seglitide illustrates how medicinal chemists reduce a 14-residue hormone to a compact, more stable analog while retaining receptor activity.
Research role
Seglitide has been used experimentally to probe somatostatin receptor subtypes and downstream signaling, including inhibition of hormone secretion. Reported pharmacology can vary by tissue, making it a useful comparator in receptor studies.
FAQ about Seglitide
What is Seglitide?+
Seglitide (MK-678) is a synthetic cyclic hexapeptide analog of somatostatin with strong activity at the SSTR2 receptor subtype. It has been used as a research tool to study somatostatin receptor pharmacology and is not an approved medicine authorized by Health Canada. This page is educational and is not medical advice.
Is Seglitide an approved medicine?+
Seglitide is discussed here as a research / educational topic. Investigational/research somatostatin analog; not an approved medicine and not authorized by Health Canada. This is not medical advice.
What is the typical length of Seglitide?+
Seglitide is commonly described as approximately 6 amino acids (Somatostatin analog (cyclic hexapeptide)).