Page data last changed: . Registry refreshes and identity assessments are separate from scientific content review.
A polypeptide complex rather than a single defined peptide sequence.
Part of the Neuropeptides & signaling cluster
Overview
Cortexin is a low-molecular-weight polypeptide complex extracted from cerebral cortex tissue, studied largely in Russian neuroscience literature. It is marketed as a drug in some countries but is not authorized by Health Canada.
Source & context
Biological / chemical source: Bovine (or porcine) cerebral cortex extract
Primary research or clinical context: Marketed as a drug in some countries; not authorized by Health Canada
A mixture, not one peptide
Unlike single-sequence peptides, cortexin is a defined-molecular-weight fraction of many short peptides and amino acids. This is why it has no single sequence and is described as a polypeptide complex in the literature.
Evidence and regulatory note
Most published studies originate from a limited set of laboratories and use animal or small clinical designs. Availability differs by country; this page is educational and does not present cortexin as a treatment.
Structure & chemistry
Molecular identity & reference confidence
Reference mass unavailable
Reference values are taken from the cited molecular record or curated profile. A database match is not independent laboratory verification; modifications, counter-ions, and formulations can change the measured mass.
- Molecular form
- Cortexin (source record; form not independently established)
- Species
- Not established by this molecular identity audit
- Termini (N / C)
- Not specified / Not specified
Average reference mass
Reference policy updated: 2026-10-05
FAQ about Cortexin
What is Cortexin?+
Cortexin is a low-molecular-weight polypeptide complex extracted from cerebral cortex tissue, studied largely in Russian neuroscience literature. It is marketed as a drug in some countries but is not authorized by Health Canada.
What Canadian product status is recorded for Cortexin?+
Canadian product status for Cortexin has not been verified in this profile. No verified record here does not mean no authorization exists. Status depends on the product, formulation and use; consult Health Canada's product records.
What is the typical length of Cortexin?+
Cortexin is not a classic amino-acid chain peptide in the same sense; see the profile for classification details.
Related peptides
References & further reading
- 1.Yazar et al. (2023). Cortexin® Ameliorates High Glucose-Induced Neuropathy in Cultured Rat Sensory Neurons. Neuroendocrinology
- 2.Tunçcan et al. (2016). Efficacy of Cortexin and Methylprednisolone on Traumatic Facial Nerve Paralysis. J Int Adv Otol
- 3.Gomazkov (2015). [Cortexin. Molecular mechanisms and targets of neuroprotective activity]. Zh Nevrol Psikhiatr Im S S Korsakova
- 4.Kurkin et al. (2021). Neuroprotective action of Cortexin, Cerebrolysin and Actovegin in acute or chronic brain ischemia in rats. PLoS One
- 5.Yakovlev et al. (2017). [Peptide drug cortexin inhibits brain caspase-8]. Biomed Khim
- 6.Kurkin et al. (2025). Neurotropic Effects of Cortexin on Models of Mental and Physical Developmental Delay. Biomedicines
- 7.Guven et al. (2026). Cortexin modulates OPG/RANK/RANKL and TRPC1 expression in cerebral ischemia-reperfusion injury. Neurol Res
- 8.Fedin et al. (2025). [Therapeutic equivalence of intravenous and intramuscular dosage forms of Cortexin in ischemic strokes]. Zh Nevrol Psikhiatr Im S S Korsakova
- 9.PubMed — Gulyaeva, molecular mechanisms of brain peptide-containing drugs: cortexin (2018, PMID 30499504)