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Research peptide

Pinealon

Pinealon is a synthetic tripeptide (Glu-Asp-Arg, EDR) from the Khavinson short-peptide bioregulator class. It has been studied for proposed neuroprotective and gene-regulatory effects in mostly Russian laboratory research and is not authorized as a medicine by Health Canada.

By The Peptides Codex Editorial TeamReviewed July 10, 2026
Length
3 aa
Class
Research peptide
Function
Short-peptide bioregulator studied for neuroprotective signaling
Context
Investigational research compound (not authorized by Health Canada)

Synthetic tripeptide (Glu-Asp-Arg) from the Khavinson bioregulator research tradition.

Also known as: EDR · Glu-Asp-Arg

Part of the Neuropeptides & signaling cluster

Overview

Pinealon is a synthetic tripeptide (Glu-Asp-Arg, EDR) from the Khavinson short-peptide bioregulator class. It has been studied for proposed neuroprotective and gene-regulatory effects in mostly Russian laboratory research and is not authorized as a medicine by Health Canada.

Source & context

Biological / chemical source: Synthetic tripeptide (Khavinson short-peptide class)

Primary research or clinical context: Investigational research compound (not authorized by Health Canada)

Short-peptide bioregulator concept

The Khavinson group proposes that very short peptides such as EDR can interact with regulatory DNA regions and influence gene expression. This hypothesis is central to how pinealon is framed in the primary literature.

Evidence status

Reported antihypoxic and neuroprotective findings derive largely from affiliated laboratories and animal models, with limited independent replication. This page describes that research context and offers no medical or dosing advice.

Sequence

One-letter sequence commonly cited for Pinealon (educational; isoforms and modifications may differ):

EDR

EDR

E1D2R3
Helical wheel projection

Residues plotted ~100° apart around an α-helix — clustering of one color reveals an amphipathic face.

Analyze sequences in the playground →

FAQ about Pinealon

What is Pinealon?+

Pinealon is a synthetic tripeptide (Glu-Asp-Arg, EDR) from the Khavinson short-peptide bioregulator class. It has been studied for proposed neuroprotective and gene-regulatory effects in mostly Russian laboratory research and is not authorized as a medicine by Health Canada.

Is Pinealon an approved medicine?+

Pinealon is discussed here as a research / educational topic. Investigational research compound (not authorized by Health Canada). This is not medical advice.

What is the typical length of Pinealon?+

Pinealon is commonly described as approximately 3 amino acids (Research peptide).

Related peptides

References & further reading

  1. 1.PubMed — Khavinson et al., EDR peptide and gene/protein regulation in AD pathogenesis (2020, PMID 33396470)
  2. 2.PubMed — Investigation of antihypoxic properties of short peptides (2008, PMID 18546825)
Disclaimer: Educational content only. Not medical advice. Not instructions for human use. Research peptides and unapproved products may be restricted or illegal to market for human consumption in your jurisdiction. Consult qualified professionals and applicable law.
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Cite this: Peptides Codex — Pinealon educational profile.
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