N-terminal pyroglutamate 13-mer that interacts with dopamine systems.
Also known as: NT
Part of the Neuropeptides & signaling cluster
Overview
Neurotensin is a 13-amino-acid neuropeptide found in the brain and gut. Research examines its interactions with dopamine signaling and its roles as a neuromodulator and local hormone.
Source & context
Biological / chemical source: Brain and gastrointestinal tract
Primary research or clinical context: Neuroscience research
Structure and activity
The biologically active region is the C-terminal portion of the peptide, and the mature form carries a pyroglutamate at its N-terminus. Its interplay with dopaminergic pathways makes neurotensin a frequent subject of basic neuroscience research.
Dual central and peripheral roles
Neurotensin functions both as a central neuromodulator and as a peripheral signaling peptide in the digestive tract. Educational discussion here focuses on this physiology, not on any therapeutic application.
Sequence
One-letter sequence commonly cited for Neurotensin (educational; isoforms and modifications may differ):
ELYENKPRRPYIL
Residues plotted ~100° apart around an α-helix — clustering of one color reveals an amphipathic face.
FAQ about Neurotensin
What is Neurotensin?+
Neurotensin is a 13-amino-acid neuropeptide found in the brain and gut. Research examines its interactions with dopamine signaling and its roles as a neuromodulator and local hormone.
Is Neurotensin an approved medicine?+
Neurotensin is discussed here as a research / educational topic. Neuroscience research. This is not medical advice.
What is the typical length of Neurotensin?+
Neurotensin is commonly described as approximately 13 amino acids (Neuropeptide).