An anorexigenic neuropeptide whose loss produces obesity in mice — a magnet for appetite research.
Also known as: NmU · NMU · NmU-25
Part of the Neuropeptides & signaling cluster
Overview
Neuromedin U (NmU) is a neuropeptide found in brain and gut, first isolated in 1985 for its uterus-contracting activity. Acting through the NMUR1 and NMUR2 receptors, it suppresses appetite and influences energy balance, making it a target in metabolism research. This page is educational and describes an endogenous peptide, not a product.
Source & context
Biological / chemical source: Human brain and gut (endogenous; human form is the 25-residue NmU-25)
Primary research or clinical context: Endogenous neuropeptide and target in metabolism and appetite research; not a Health Canada-authorized product
Structure and receptors
The human peptide is NmU-25, a 25-residue amidated neuropeptide, with shorter active forms found across species. It signals through two G-protein-coupled receptors, NMUR1 (more peripheral) and NMUR2 (more central), a receptor split that helps explain its wide range of actions from smooth-muscle contraction to central appetite control.
Why metabolism researchers care
Within the hypothalamus neuromedin U acts as an anorexigenic signal, suppressing appetite and promoting energy expenditure. Deleting the NMU gene in mice produces an obese, hyperphagic phenotype, while overexpression reduces fat storage — findings that make the NmU system a focus of obesity and metabolism research. This page is educational and makes no treatment claim.
FAQ about Neuromedin U
What is Neuromedin U?+
Neuromedin U (NmU) is a neuropeptide found in brain and gut, first isolated in 1985 for its uterus-contracting activity. Acting through the NMUR1 and NMUR2 receptors, it suppresses appetite and influences energy balance, making it a target in metabolism research. This page is educational and describes an endogenous peptide, not a product.
Is Neuromedin U an approved medicine?+
Neuromedin U is discussed here as a research / educational topic. Endogenous neuropeptide and target in metabolism and appetite research; not a Health Canada-authorized product. This is not medical advice.
What is the typical length of Neuromedin U?+
Neuromedin U is commonly described as approximately 25 amino acids (Neuropeptide).