A splice variant of IGF-1 whose distinct E-domain gives it a separate identity.
Also known as: mechano growth factor · IGF-1Ec
Part of the Growth hormone & IGF peptides cluster
Overview
MGF (mechano growth factor) is a splice variant of insulin-like growth factor 1 (IGF-1) that shares the mature IGF-1 region but carries a different E-domain. Research peptides often use its ~24-residue C-terminal E-domain fragment. It is investigational and not authorized by Health Canada; this page is educational only.
Source & context
Biological / chemical source: C-terminal fragment of an alternatively spliced IGF-1 transcript
Primary research or clinical context: Investigational research peptide; not authorized by Health Canada
Relationship to IGF-1
The IGF1 gene can be spliced into forms with different E-domains. One variant is mechano growth factor, expressed in muscle after mechanical load or damage. It shares the mature IGF-1 sequence but its unique C-terminal peptide is what distinguishes MGF and is the portion most studied on its own.
Research context and status
MGF is studied for a possible role in activating muscle satellite cells during repair, and it appears on anti-doping prohibited lists. Evidence in humans is limited and preliminary. It is an investigational compound, not an approved drug in Canada, and nothing here should be read as endorsing use.
FAQ about MGF
What is MGF?+
MGF (mechano growth factor) is a splice variant of insulin-like growth factor 1 (IGF-1) that shares the mature IGF-1 region but carries a different E-domain. Research peptides often use its ~24-residue C-terminal E-domain fragment. It is investigational and not authorized by Health Canada; this page is educational only.
Is MGF an approved medicine?+
MGF is discussed here as a research / educational topic. Investigational research peptide; not authorized by Health Canada. This is not medical advice.
What is the typical length of MGF?+
MGF is commonly described as approximately 24 amino acids (IGF-1 splice-variant peptide).