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Designed to work through enkephalin receptors, and often paired with Argireline in the Argirelox blend.
Also known as: Pentapeptide-18
Part of the Cosmetic & skin peptides cluster
Overview
Leuphasyl (INCI: Pentapeptide-18) is a synthetic cosmetic peptide modeled on natural enkephalins, marketed to reduce the appearance of expression wrinkles. It is often combined with Argireline. This page describes it as a cosmetic ingredient for education only and makes no drug or medical claim.
Source & context
Biological / chemical source: Synthetic biomimetic pentapeptide modeled on natural enkephalin opioid peptides
Primary research or clinical context: Cosmetic ingredient (INCI: Pentapeptide-18), used topically in anti-wrinkle formulations; framed as a cosmetic ingredient, not a drug
Enkephalin-inspired design
Leuphasyl is a biomimetic pentapeptide whose design references the natural enkephalin opioid peptides. In cosmetic literature it is described as acting at enkephalin receptors on nerve cells to modulate signalling associated with repeated micro-contractions, the movements linked to the look of expression lines around the eyes and forehead.
Formulation and framing
It is frequently paired with Acetyl Hexapeptide-8 (Argireline) in a blend marketed as Argirelox, on the rationale that the two act at different points in the same pathway. As a cosmetic ingredient it is discussed in terms of the appearance of wrinkles. This page is educational and does not claim any physiological treatment effect.
Structure & chemistry
Molecular identity & reference confidence
Source-supported reference
Reference values are taken from the cited molecular record or curated profile. A database match is not independent laboratory verification; modifications, counter-ions, and formulations can change the measured mass.
- Molecular form
- Leuphasyl (source record; form not independently established)
- Species
- Not established by this molecular identity audit
- Termini (N / C)
- Not specified / Not specified
Average reference mass
Reference policy updated: 2026-10-05
- PubChem molecular record · 2026-10-01
- Molecular formula
- C29H39N5O7
- Average reference mass
- ≈ 569.6
- PubChem CID: 10099522
- CAS RN: 64963-01-5
- UNII: PO4D55T1IG
Chemistry values: PubChem · fetched 2026-10-01.
Leuphasyl — reconstitution calculator
Enter how much peptide is in the vial and how much diluent (e.g. bacteriostatic water) is added. The tool returns the resulting solution concentration — and, for any amount you type, the volume it corresponds to. This is educational arithmetic, not a dosing recommendation.
Reference form: Leuphasyl (source record; form not independently established)Average reference mass: 569.6 Da
Enter an amount to see the volume it corresponds to.
Educational concentration mathematics only. This tool does not recommend a dose, amount, or protocol, and nothing here is medical advice. Many peptides are not authorized by Health Canada for human use — see our reconstitution and bacteriostatic-water guides for context.
FAQ about Leuphasyl
What is Leuphasyl?+
Leuphasyl (INCI: Pentapeptide-18) is a synthetic cosmetic peptide modeled on natural enkephalins, marketed to reduce the appearance of expression wrinkles. It is often combined with Argireline. This page describes it as a cosmetic ingredient for education only and makes no drug or medical claim.
What Canadian product status is recorded for Leuphasyl?+
Canadian product status for Leuphasyl has not been verified in this profile. No verified record here does not mean no authorization exists. Status depends on the product, formulation and use; consult Health Canada's product records.
What is the typical length of Leuphasyl?+
Leuphasyl is commonly described as approximately 5 amino acids (Cosmetic neuro-peptide (INCI ingredient)).
Related peptides
References & further reading
- 1.Akhan et al. (2026). Integrative In Silico and In Vitro Evaluation of Vialox and Leuphasyl Pentapeptides for Antiaging Applications. Chem Biodivers
- 2.Akhan et al. (2026). Pentapeptide-18 as an anti-aging candidate: Spectroscopic characterization and molecular interaction analysis. Comput Biol Chem
- 3.Typology — What is Pentapeptide-18 (Leuphasyl)?
- 4.ScienceDirect — Pentapeptide-18 as an anti-aging candidate: spectroscopic characterization