Page data last changed: . Chemistry registry snapshot: . Registry refreshes and identity assessments are separate from scientific content review.
Key peptide in GnRH pulse / fertility axis research.
Also known as: Kp-10 · metastin fragment
Part of the Neuropeptides & signaling cluster
Overview
Kisspeptin-10 is a decapeptide fragment that activates the kisspeptin receptor (KISS1R), a central node in reproductive hormone regulation research.
Source & context
Biological / chemical source: Synthetic fragment of kisspeptin
Primary research or clinical context: Reproductive endocrinology research
Axis biology
Kisspeptin neurons help gate GnRH release. Short fragments like Kp-10 are used experimentally to probe this pathway.
Sequence
One-letter sequence commonly cited for Kisspeptin-10 (educational; isoforms and modifications may differ):
YNWNSFGLRF
Residues plotted ~100° apart around an α-helix — clustering of one color reveals an amphipathic face.
Structure & chemistry
Molecular identity & reference confidence
Source-supported reference
Reference values are taken from the cited molecular record or curated profile. A database match is not independent laboratory verification; modifications, counter-ions, and formulations can change the measured mass.
- Molecular form
- Kisspeptin-10 (source record; form not independently established)
- Species
- Not established by this molecular identity audit
- Termini (N / C)
- Not specified / Not specified
Average reference mass
Reference policy updated: 2026-10-05
- IUPHAR/BPS source snapshot · 2026-10-01
- PubChem molecular record · 2026-10-01
- Molecular formula
- C63H83N17O14
- Average reference mass
- ≈ 1,302.4
- PubChem CID: 25240297
- IUPHAR ligand: 1283
- ChEMBL: CHEMBL376756
- CAS RN: 374675-21-5
- UNII: FS1N52VS3S
Chemistry values: IUPHAR/BPS Guide to Pharmacology, PubChem · fetched 2026-10-01.
Clinical development snapshot
ClinicalTrials.gov lists 5 registered studies with “Kisspeptin-10” as an intervention (snapshot 2026-09-06). A registry footprint is not evidence of efficacy or approval.
| NCT | Title | Phase | Status | Updated |
|---|---|---|---|---|
| NCT05456854 | Evaluation of Kisspeptin Stimulated Insulin Secretion With Hyperglycemic Clamp | Phase 1 | withdrawn | 2024-08-14 |
| NCT04532801 | Evaluation of Kisspeptin Glucose-Stimulated Insulin Secretion With Physiologic Mixed Meal Tolerance | Phase 1 | withdrawn | 2024-08-01 |
| NCT03771326 | KP-10 and Insulin Secretion in Men | Phase 3 | completed | 2018-12-12 |
| NCT03315325 | Age-dependent Changes in the Responsiveness of Hypothalamic Pituitary Gonadal Axis in Men | Phase 3 | completed | 2017-10-23 |
| NCT03286517 | Link Between the Sensitivity of Kisspeptin Signalling and Pubertal Onset in Boys. | Phase 3 | completed | 2017-09-18 |
Kisspeptin-10 — reconstitution calculator
Enter how much peptide is in the vial and how much diluent (e.g. bacteriostatic water) is added. The tool returns the resulting solution concentration — and, for any amount you type, the volume it corresponds to. This is educational arithmetic, not a dosing recommendation.
Reference form: Kisspeptin-10 (source record; form not independently established)Average reference mass: 1,302.4 Da
Enter an amount to see the volume it corresponds to.
Educational concentration mathematics only. This tool does not recommend a dose, amount, or protocol, and nothing here is medical advice. Many peptides are not authorized by Health Canada for human use — see our reconstitution and bacteriostatic-water guides for context.
FAQ about Kisspeptin-10
What is Kisspeptin-10?+
Kisspeptin-10 is a decapeptide fragment that activates the kisspeptin receptor (KISS1R), a central node in reproductive hormone regulation research.
What Canadian product status is recorded for Kisspeptin-10?+
Canadian product status for Kisspeptin-10 has not been verified in this profile. No verified record here does not mean no authorization exists. Status depends on the product, formulation and use; consult Health Canada's product records.
What is the typical length of Kisspeptin-10?+
Kisspeptin-10 is commonly described as approximately 10 amino acids (Research peptide).
Related peptides
References & further reading
- 1.Colpaert et al. (2024). Investigating the detection of the novel doping‐relevant peptide kisspeptin‐10 in urine using liquid chromatography high‐resolution mass spectrometry. Biomed Chromatogr
- 2.Li et al. (2024). Kisspeptin-10 binding to Gpr54 in osteoclasts prevents bone loss by activating Dusp18-mediated dephosphorylation of Src. Nat Commun
- 3.Son et al. (2018). Kisspeptin-10 (KP-10) stimulates osteoblast differentiation through GPR54-mediated regulation of BMP2 expression and activation. Sci Rep
- 4.Radwańska et al. (2023). Kisspeptin-10 increases collagen content in the myocardium by focal adhesion kinase activity. Sci Rep
- 5.Simon et al. (2023). Kisspeptin-10 Mitigates α-Synuclein-Mediated Mitochondrial Apoptosis in SH-SY5Y-Derived Neurons via a Kisspeptin Receptor-Independent Manner. Int J Mol Sci
- 6.Li et al. (2025). Kisspeptin-10 Preserves the Blood-Brain Barrier's Integrity Post-Stroke by Augmenting Claudin-10 Expression. Clin Exp Pharmacol Physiol
- 7.Sridhar et al. (2025). Kisspeptin-10 Ameliorates Obesity-Diabetes with Diverse Effects on Ileal Enteroendocrine Cells and Pancreatic Islet Morphology in High-Fat Fed Female Mice. Biomolecules
- 8.Cheng et al. (2025). Kisspeptin-10 protects against HIV-1 Tat-induced blood-brain barrier dysfunction and neuroinflammation via RhoA/ROCK pathway: Implications for HAND therapy. Neurotoxicology
- 9.PubChem — compound summary for Kisspeptin-10 (CID 25240297)
- 10.Wikipedia — Kisspeptin