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Research peptide

GHRP-2

GHRP-2 (pralmorelin) is a synthetic growth hormone–releasing peptide that acts at the ghrelin receptor. It is a foundational compound in GH secretagogue research education.

By The Peptides Codex Editorial TeamIndividual review date not recorded

Page data last changed: . Chemistry registry snapshot: . Registry refreshes and identity assessments are separate from scientific content review.

Length
6 aa
Class
Research peptide
Function
Ghrelin receptor agonist / GH secretagogue
Context
Research compound; pralmorelin has diagnostic uses in some countries

Classic GHRP used in GH-axis research and older clinical diagnostics.

Also known as: pralmorelin · GHRP2

Part of the Growth hormone & IGF peptides cluster

Overview

GHRP-2 (pralmorelin) is a synthetic growth hormone–releasing peptide that acts at the ghrelin receptor. It is a foundational compound in GH secretagogue research education.

Source & context

Biological / chemical source: Synthetic hexapeptide

Primary research or clinical context: Research compound; pralmorelin has diagnostic uses in some countries

GHRP family

GHRP-2 sits alongside GHRP-6, hexarelin, and ipamorelin in the growth hormone secretagogue conversation. Selectivity and side-effect profiles differ across the class.

Research framing

Literature examines GH release, appetite signaling, and receptor pharmacology. Online protocols are not a substitute for controlled research design or medical care.

Sequence

One-letter sequence commonly cited for GHRP-2 (educational; isoforms and modifications may differ):

AAAWFK

AAAWFK

GHRP-26 aa · C45H55N9O6 · ≈ 818 DaPEPTIDESCODEX.COMN-terminus →→ C-terminusA1A2A3W4F5K+6nonpolarpolaracidicbasicGly / Pronon-canonical (X)Hydropathy (Kyte–Doolittle): ▮ hydrophobic (cyan) / ▮ hydrophilic (rose) · Side-chain charge at pH 7: + / −
GHRP-2 — Structure cardDownload SVG
A1A2A3W4F5K6
Helical wheel projection

Residues plotted ~100° apart around an α-helix — clustering of one color reveals an amphipathic face.

Analyze sequences in the playground →

Structure & chemistry

Molecular identity & reference confidence

Source-supported reference

Reference values are taken from the cited molecular record or curated profile. A database match is not independent laboratory verification; modifications, counter-ions, and formulations can change the measured mass.

Molecular form
GHRP-2 (source record; form not independently established)
Species
Not established by this molecular identity audit
Termini (N / C)
Not specified / Not specified

Average reference mass

Reference policy updated: 2026-10-05

Molecular formula
C45H55N9O6
Average reference mass
≈ 818
Status
Approved medicine in at least one jurisdiction (IUPHAR record)
Chemical modifications (IUPHAR record)

C-terminal lysine is amidated; alanine residue at position 2 is 2-naphthalenyl-alanine (Nal)

Identifiers

Chemistry values: IUPHAR/BPS Guide to Pharmacology, PubChem · fetched 2026-10-01.

Concentration math

GHRP-2 — reconstitution calculator

Enter how much peptide is in the vial and how much diluent (e.g. bacteriostatic water) is added. The tool returns the resulting solution concentration — and, for any amount you type, the volume it corresponds to. This is educational arithmetic, not a dosing recommendation.

Reference form: GHRP-2 (source record; form not independently established)Average reference mass: 818 Da

Syringe graduation
Solution concentration
5 mg/mL5,000 mcg/mL
mcg

Enter an amount to see the volume it corresponds to.

Educational concentration mathematics only. This tool does not recommend a dose, amount, or protocol, and nothing here is medical advice. Many peptides are not authorized by Health Canada for human use — see our reconstitution and bacteriostatic-water guides for context.

Open the GHRP-2 calculator on its own page →

FAQ about GHRP-2

What is GHRP-2?+

GHRP-2 (pralmorelin) is a synthetic growth hormone–releasing peptide that acts at the ghrelin receptor. It is a foundational compound in GH secretagogue research education.

What Canadian product status is recorded for GHRP-2?+

Canadian product status for GHRP-2 has not been verified in this profile. No verified record here does not mean no authorization exists. Status depends on the product, formulation and use; consult Health Canada's product records.

What is the typical length of GHRP-2?+

GHRP-2 is commonly described as approximately 6 amino acids (Research peptide).

Related peptides

MK-677
Research compound
MK-677 (ibutamoren) is an orally active ghrelin receptor agonist often searched alongside peptide GH secretagogues. It is a small molecule, not a peptide, but belongs to the same research conversation.
Melanotan II
Cyclic melanocortin-receptor agonist (unlicensed research peptide)
Melanotan II is a synthetic cyclic heptapeptide analogue of α-melanocyte-stimulating hormone (Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH2) that non-selectively activates melanocortin receptors, producing skin darkening through MC1R and erections and appetite effects through MC4R. It has never been approved anywhere and is sold unlawfully online for tanning; the published human literature consists largely of case reports of rhabdomyolysis, renal infarction and melanoma coinciding with its use. A phase 2 trial as an adjunct to phototherapy was registered in 2026.
GHRP-6
Research peptide
GHRP-6 is a synthetic hexapeptide growth hormone secretagogue acting at the ghrelin receptor, frequently discussed for GH release and appetite-related experimental findings.
Hexarelin
Research peptide
Hexarelin (examorelin) is a synthetic hexapeptide growth hormone secretagogue studied for potent GH-releasing activity and related receptor pharmacology.

References & further reading

  1. 1.Okano et al. (2010). Determination of growth hormone secretagogue pralmorelin (GHRP-2) and its metabolite in human urine by liquid chromatography/electrospray ionization tandem mass spectrometry. Rapid Commun Mass Spectrom
  2. 2.Doi et al. (2004). Pharmacological characteristics of KP-102 (GHRP-2), a potent growth hormone-releasing peptide. Arzneimittelforschung
  3. 3.Laferrère et al. (2005). Growth hormone releasing peptide-2 (GHRP-2), like ghrelin, increases food intake in healthy men. J Clin Endocrinol Metab
  4. 4.Hayakawa et al. (2018). Evaluation of Hypothalamic-Pituitary-Adrenal Axis by the GHRP2 Test: Comparison With the Insulin Tolerance Test. J Endocr Soc
  5. 5.Semenistaya et al. (2015). Determination of growth hormone releasing peptides metabolites in human urine after nasal administration of GHRP-1, GHRP-2, GHRP-6, Hexarelin, and Ipamorelin. Drug Test Anal
  6. 6.Popławska et al. (2019). Identification of a novel growth hormone releasing peptide (a glycine analogue of GHRP-2) in a seized injection vial. Drug Test Anal
  7. 7.Granado et al. (2005). Anti-inflammatory effect of the ghrelin agonist growth hormone-releasing peptide-2 (GHRP-2) in arthritic rats. Am J Physiol Endocrinol Metab
  8. 8.Chen et al. (1998). Growth hormone-releasing peptide-2 (GHRP-2) does not act via the human growth hormone-releasing factor receptor in GC cells. Endocrine
  9. 9.PubChem — compound summary for Pralmorelin / GHRP-2 (CID 6918245)
  10. 10.Wikipedia — Pralmorelin (GHRP-2)
Disclaimer: Educational content only. Not medical advice. Not instructions for human use. Research peptides and unapproved products may be restricted or illegal to market for human consumption in your jurisdiction. Consult qualified professionals and applicable law.
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