Page data last changed: . Chemistry registry snapshot: . Registry refreshes and identity assessments are separate from scientific content review.
Known for robust GH secretagogue activity and appetite-related signaling in research models.
Also known as: GHRP6
Part of the Growth hormone & IGF peptides cluster
Overview
GHRP-6 is a synthetic hexapeptide growth hormone secretagogue acting at the ghrelin receptor, frequently discussed for GH release and appetite-related experimental findings.
Source & context
Biological / chemical source: Synthetic hexapeptide
Primary research or clinical context: Research compound (not an approved chronic therapy in most markets)
Comparison context
Relative to ipamorelin, GHRP-6 is often described as less selective, with more reported effects on appetite and other pathways in experimental and secondary literature.
Sequence
One-letter sequence commonly cited for GHRP-6 (educational; isoforms and modifications may differ):
HWAWFK
Residues plotted ~100° apart around an α-helix — clustering of one color reveals an amphipathic face.
Structure & chemistry
Molecular identity & reference confidence
Source-supported reference
Reference values are taken from the cited molecular record or curated profile. A database match is not independent laboratory verification; modifications, counter-ions, and formulations can change the measured mass.
- Molecular form
- GHRP-6 (source record; form not independently established)
- Species
- Not established by this molecular identity audit
- Termini (N / C)
- Not specified / Not specified
Average reference mass
Reference policy updated: 2026-10-05
- IUPHAR/BPS source snapshot · 2026-10-01
- PubChem molecular record · 2026-10-01
- Molecular formula
- C46H56N12O6
- Average reference mass
- ≈ 873
N-terminal histidine residue is methylated; C-terminal lysine is amidated
Chemistry values: IUPHAR/BPS Guide to Pharmacology, PubChem · fetched 2026-10-01.
GHRP-6 — reconstitution calculator
Enter how much peptide is in the vial and how much diluent (e.g. bacteriostatic water) is added. The tool returns the resulting solution concentration — and, for any amount you type, the volume it corresponds to. This is educational arithmetic, not a dosing recommendation.
Reference form: GHRP-6 (source record; form not independently established)Average reference mass: 873 Da
Enter an amount to see the volume it corresponds to.
Educational concentration mathematics only. This tool does not recommend a dose, amount, or protocol, and nothing here is medical advice. Many peptides are not authorized by Health Canada for human use — see our reconstitution and bacteriostatic-water guides for context.
FAQ about GHRP-6
What is GHRP-6?+
GHRP-6 is a synthetic hexapeptide growth hormone secretagogue acting at the ghrelin receptor, frequently discussed for GH release and appetite-related experimental findings.
What Canadian product status is recorded for GHRP-6?+
Canadian product status for GHRP-6 has not been verified in this profile. No verified record here does not mean no authorization exists. Status depends on the product, formulation and use; consult Health Canada's product records.
What is the typical length of GHRP-6?+
GHRP-6 is commonly described as approximately 6 amino acids (Research peptide).
Related peptides
References & further reading
- 1.Zhao et al. (2025). Growth hormone-releasing peptide 6 (GHRP-6) hydrogel for acute kidney injury therapy via metabolic regulation. J Nanobiotechnology
- 2.Pombo et al. (1996). Growth hormone releasing hexapeptide-6 (GHRP-6) test in the diagnosis of GH-deficiency. J Pediatr Endocrinol Metab
- 3.Haijma et al. (2005). The GHRH/GHRP-6 test for the diagnosis of GH deficiency in elderly or severely obese men. Eur J Endocrinol
- 4.Berlanga-Acosta et al. (2024). Growth hormone releasing peptide-6 (GHRP-6) prevents doxorubicin-induced myocardial and extra-myocardial damages by activating prosurvival mechanisms. Front Pharmacol
- 5.Berlanga et al. (2007). Growth-hormone-releasing peptide 6 (GHRP6) prevents oxidant cytotoxicity and reduces myocardial necrosis in a model of acute myocardial infarction. Clin Sci (Lond)
- 6.Micic et al. (1995). Growth hormone secretion after the administration of GHRP-6 or GHRH combined with GHRP-6 does not decline in late adulthood. Clin Endocrinol (Oxf)
- 7.Petersenn et al. (2002). Diagnosis of growth hormone deficiency in adults by testing with GHRP-6 alone or in combination with GHRH: comparison with the insulin tolerance test. Eur J Endocrinol
- 8.Popovic et al. (1998). Growth hormone secretion elicited by GHRH, GHRP-6 or GHRH plus GHRP-6 in patients with microprolactinoma and macroprolactinoma before and after bromocriptine therapy. Clin Endocrinol (Oxf)
- 9.PubChem — compound summary for GHRP-6 (CID 4345065)
- 10.Wikipedia — GHRP-6