A vasopressin analog engineered for antidiuretic action without vasoconstriction.
Also known as: DDAVP
Part of the Foundational & therapeutic peptides cluster
Overview
Desmopressin (DDAVP) is a synthetic nonapeptide analog of vasopressin, modified by deamination of the first residue and a D-arginine substitution. These changes favor V2-mediated antidiuresis while minimizing V1 vasoconstriction, and it is an approved therapeutic for diabetes insipidus, nocturnal enuresis and some bleeding disorders. This page is educational and not medical advice.
Source & context
Biological / chemical source: Synthetic nonapeptide analog of vasopressin
Primary research or clinical context: Approved for diabetes insipidus, bedwetting and certain bleeding disorders
Selective redesign
Two structural changes to vasopressin extend the half-life and shift activity toward the V2 receptor. The result is strong water-retaining action with little blood-pressure effect, a frequently cited example of receptor selectivity achieved by minimal peptide modification.
Hemostatic use
Beyond fluid balance, desmopressin triggers release of von Willebrand factor and factor VIII from endothelial stores, which is why it is used in mild hemophilia A and von Willebrand disease. This dual profile makes it a versatile teaching example of peptide pharmacology.
FAQ about Desmopressin
What is Desmopressin?+
Desmopressin (DDAVP) is a synthetic nonapeptide analog of vasopressin, modified by deamination of the first residue and a D-arginine substitution. These changes favor V2-mediated antidiuresis while minimizing V1 vasoconstriction, and it is an approved therapeutic for diabetes insipidus, nocturnal enuresis and some bleeding disorders. This page is educational and not medical advice.
Is Desmopressin an approved medicine?+
Desmopressin: Approved for diabetes insipidus, bedwetting and certain bleeding disorders. Always follow licensed medical guidance for approved products.
What is the typical length of Desmopressin?+
Desmopressin is commonly described as approximately 9 amino acids (Vasopressin analog).