One of the most potent known vasodilators; central to migraine research.
Also known as: Calcitonin gene-related peptide
Part of the Neuropeptides & signaling cluster
Overview
CGRP (calcitonin gene-related peptide) is a 37-amino-acid neuropeptide produced by alternative splicing of the calcitonin gene. It is a potent vasodilator and a major focus of migraine and pain-signaling research.
Source & context
Biological / chemical source: Alternative splicing of the CALCA gene; sensory neurons
Primary research or clinical context: Migraine and pain neuroscience research
One gene, two peptides
Tissue-specific alternative splicing of the CALCA gene yields either calcitonin or CGRP — a textbook example of how a single gene can encode distinct signaling peptides. CGRP predominates in neural tissue.
Research relevance
CGRP receptor biology has become one of the most studied areas in headache neuroscience. This page summarizes that physiology for education and does not offer treatment or dosing guidance.
FAQ about CGRP
What is CGRP?+
CGRP (calcitonin gene-related peptide) is a 37-amino-acid neuropeptide produced by alternative splicing of the calcitonin gene. It is a potent vasodilator and a major focus of migraine and pain-signaling research.
Is CGRP an approved medicine?+
CGRP is discussed here as a research / educational topic. Migraine and pain neuroscience research. This is not medical advice.
What is the typical length of CGRP?+
CGRP is commonly described as approximately 37 amino acids (Neuropeptide).