Page data last changed: . Chemistry registry snapshot: . Registry refreshes and identity assessments are separate from scientific content review.
One of the most potent known vasodilators; central to migraine research.
Also known as: Calcitonin gene-related peptide
Part of the Neuropeptides & signaling cluster
Overview
CGRP (calcitonin gene-related peptide) is a 37-amino-acid neuropeptide produced by alternative splicing of the calcitonin gene. It is a potent vasodilator and a major focus of migraine and pain-signaling research.
Source & context
Biological / chemical source: Alternative splicing of the CALCA gene; sensory neurons
Primary research or clinical context: Migraine and pain neuroscience research
One gene, two peptides
Tissue-specific alternative splicing of the CALCA gene yields either calcitonin or CGRP — a textbook example of how a single gene can encode distinct signaling peptides. CGRP predominates in neural tissue.
Research relevance
CGRP receptor biology has become one of the most studied areas in headache neuroscience. This page summarizes that physiology for education and does not offer treatment or dosing guidance.
Structure & chemistry
Molecular identity & reference confidence
Source-supported reference
Reference values are taken from the cited molecular record or curated profile. A database match is not independent laboratory verification; modifications, counter-ions, and formulations can change the measured mass.
- Molecular form
- CGRP (source record; form not independently established)
- Species
- Not established by this molecular identity audit
- Termini (N / C)
- Not specified / Not specified
Average reference mass
Reference policy updated: 2026-10-05
- IUPHAR/BPS source snapshot · 2026-10-01
- PubChem molecular record · 2026-10-01
- Molecular formula
- C163H273N51O49S2
- Average reference mass
- ≈ 3,795.4
Chemistry values: PubChem, IUPHAR/BPS Guide to Pharmacology · fetched 2026-10-01.
Clinical development snapshot
ClinicalTrials.gov lists 232 registered studies with “CGRP” as an intervention (snapshot 2026-10-01). A registry footprint is not evidence of efficacy or approval.
| NCT | Title | Phase | Status | Updated |
|---|---|---|---|---|
| NCT06584409 | Migraines Accepted Laser Acupuncture Compared in Blood Test of MMP2 and CGRP | Not applicable | recruiting | 2026-09-30 |
| NCT07599228 | Using Virtual Reality to Teach Mindfulness to People With Migraine | Not applicable | not yet recruiting | 2026-09-30 |
| NCT07846033 | A Phase 1 Study of VK3019 in Overweight and Obese Adults Without Comorbidities | Phase 1 | recruiting | 2026-09-29 |
| NCT06459648 | Study for Prevent Chronification Migraine Through Prediction of Response to Treatment With Anti-CGRP Antibodie | — | active not recruiting | 2026-09-25 |
| NCT07699549 | Long-term Atogepant in Real-world Practice | — | completed | 2026-09-23 |
| NCT05955612 | Use of Procalcitonin, a Blood Test to Guide Antibiotic Therapy for Sepsis in Adults | Phase 3 | completed | 2026-09-22 |
CGRP — reconstitution calculator
Enter how much peptide is in the vial and how much diluent (e.g. bacteriostatic water) is added. The tool returns the resulting solution concentration — and, for any amount you type, the volume it corresponds to. This is educational arithmetic, not a dosing recommendation.
Reference form: CGRP (source record; form not independently established)Average reference mass: 3,795.4 Da
Enter an amount to see the volume it corresponds to.
Educational concentration mathematics only. This tool does not recommend a dose, amount, or protocol, and nothing here is medical advice. Many peptides are not authorized by Health Canada for human use — see our reconstitution and bacteriostatic-water guides for context.
Change log
Dated observations from the data pipeline (registry flags, trial footprints, identifiers) and editorial reviews of this profile.
- Trials5 registered studies added on ClinicalTrials.gov (now 232).
FAQ about CGRP
What is CGRP?+
CGRP (calcitonin gene-related peptide) is a 37-amino-acid neuropeptide produced by alternative splicing of the calcitonin gene. It is a potent vasodilator and a major focus of migraine and pain-signaling research.
What Canadian product status is recorded for CGRP?+
Canadian product status for CGRP has not been verified in this profile. No verified record here does not mean no authorization exists. Status depends on the product, formulation and use; consult Health Canada's product records.
What is the typical length of CGRP?+
CGRP is commonly described as approximately 37 amino acids (Neuropeptide).
Related peptides
References & further reading
- 1.Wattiez et al. (2020). Calcitonin gene-related peptide (CGRP): role in migraine pathophysiology and therapeutic targeting. Expert Opin Ther Targets
- 2.Fila et al. (2023). Nutrition and Calcitonin Gene Related Peptide (CGRP) in Migraine. Nutrients
- 3.Henson et al. (2020). Calcitonin Gene-Related Peptide (CGRP) Antagonists and Their Use in Migraines. J Pain Palliat Care Pharmacother
- 4.Eller et al. (2024). Novel Calcitonin Gene-Related Peptide (CGRP) Interfering Migraine Therapies and Stroke-A Review. Int J Mol Sci
- 5.Chung (2018). Calcitonin gene-related peptide (CGRP): role in peripheral nerve regeneration. Rev Neurosci
- 6.Durham (2006). Calcitonin gene-related peptide (CGRP) and migraine. Headache
- 7.Russo (2015). Calcitonin gene-related peptide (CGRP): a new target for migraine. Annu Rev Pharmacol Toxicol
- 8.Li et al. (2025). A calcitonin gene-related peptide co-crosslinked hydrogel promotes diabetic wound healing by regulating M2 macrophage polarization and angiogenesis. Acta Biomater
- 9.UniProt — Calcitonin gene-related peptide 1 (CALCA), human (P06881)
- 10.Wikipedia — Calcitonin gene-related peptide