A synthetic copy of the 28-residue neuropeptide VIP, studied in acute lung injury.
Also known as: synthetic VIP · RLF-100 · Zyesami
Part of the Foundational & therapeutic peptides cluster
Overview
Aviptadil is an injectable synthetic form of human vasoactive intestinal peptide (VIP), a 28-amino-acid neuropeptide. It has been investigated for acute respiratory distress syndrome and other lung conditions, and a VIP-phentolamine combination has approval in some markets for erectile dysfunction. This page is educational and is not medical advice.
Source & context
Biological / chemical source: Synthetic form of human vasoactive intestinal peptide
Primary research or clinical context: Synthetic form of human VIP investigated for respiratory conditions such as ARDS; a combination with phentolamine has approval in some markets for erectile dysfunction
What VIP does
Vasoactive intestinal peptide is a signaling neuropeptide with vasodilatory, bronchodilatory, and anti-inflammatory activity. Because VIP receptors are abundant in the lung, synthetic VIP has been of interest in respiratory research.
Investigational status
Aviptadil received attention during COVID-19 research for severe respiratory failure and holds fast-track designation in the US for that context. Investigational uses remain under study rather than broadly approved.
Sequence
One-letter sequence commonly cited for Aviptadil (educational; isoforms and modifications may differ):
HSDAVFTDNYTRLRKQMAVKKYLNSILN
Residues plotted ~100° apart around an α-helix — clustering of one color reveals an amphipathic face.
FAQ about Aviptadil
What is Aviptadil?+
Aviptadil is an injectable synthetic form of human vasoactive intestinal peptide (VIP), a 28-amino-acid neuropeptide. It has been investigated for acute respiratory distress syndrome and other lung conditions, and a VIP-phentolamine combination has approval in some markets for erectile dysfunction. This page is educational and is not medical advice.
Is Aviptadil an approved medicine?+
Aviptadil is discussed here as a research / educational topic. Synthetic form of human VIP investigated for respiratory conditions such as ARDS; a combination with phentolamine has approval in some markets for erectile dysfunction. This is not medical advice.
What is the typical length of Aviptadil?+
Aviptadil is commonly described as approximately 28 amino acids (Vasoactive intestinal peptide (VIP) analog).