POMC-derived melanocortin corresponding to the ACTH(1–13) sequence.
Also known as: α-MSH · Alpha-melanocyte-stimulating hormone
Part of the Neuropeptides & signaling cluster
Overview
Alpha-MSH (alpha-melanocyte-stimulating hormone) is a 13-amino-acid melanocortin peptide processed from POMC. Research examines its roles in pigmentation, appetite regulation, and inflammation signaling.
Source & context
Biological / chemical source: Pituitary and hypothalamus; derived from POMC
Primary research or clinical context: Pigmentation and energy-balance research
Melanocortin receptors
Alpha-MSH activates melanocortin receptors (MC1R–MC5R), linking a single peptide to pigmentation, energy balance, and immune signaling depending on receptor and tissue. This receptor breadth drives broad research interest.
Relationship to related peptides
Its sequence is identical to the first 13 residues of ACTH, and it is the natural counterpart to synthetic melanocortin research peptides. This page covers that biology for education, not cosmetic or therapeutic use.
Sequence
One-letter sequence commonly cited for Alpha-MSH (educational; isoforms and modifications may differ):
SYSMEHFRWGKPV
Residues plotted ~100° apart around an α-helix — clustering of one color reveals an amphipathic face.
FAQ about Alpha-MSH
What is Alpha-MSH?+
Alpha-MSH (alpha-melanocyte-stimulating hormone) is a 13-amino-acid melanocortin peptide processed from POMC. Research examines its roles in pigmentation, appetite regulation, and inflammation signaling.
Is Alpha-MSH an approved medicine?+
Alpha-MSH is discussed here as a research / educational topic. Pigmentation and energy-balance research. This is not medical advice.
What is the typical length of Alpha-MSH?+
Alpha-MSH is commonly described as approximately 13 amino acids (Neuropeptide).