A 52-residue vasodilatory hormone first isolated from a pheochromocytoma in 1993.
Also known as: ADM · AM
Part of the Foundational & therapeutic peptides cluster
Overview
Adrenomedullin (ADM) is a 52-amino-acid peptide hormone first isolated from adrenal-medulla tumor tissue in 1993. Widely expressed and circulating, it promotes vasodilation, supports endothelial barrier integrity and helps regulate blood pressure. This page is educational and not medical advice.
Source & context
Biological / chemical source: Encoded by the ADM gene; widely expressed and circulating
Primary research or clinical context: Cardiovascular, sepsis and biomarker research
Origin and signaling
ADM is cleaved from a 185-residue precursor and signals through calcitonin-receptor-like receptor (CLR) paired with RAMP2 or RAMP3 co-receptors. It is produced by endothelium, vascular smooth muscle and many other tissues, acting through cAMP and nitric-oxide pathways.
Research and biomarker use
Adrenomedullin and its stable surrogate MR-proADM are studied as markers of endothelial function and outcomes in heart failure and sepsis. Its vasodilatory, anti-inflammatory and tissue-protective actions make the ADM system a therapeutic-target candidate.
FAQ about Adrenomedullin
What is Adrenomedullin?+
Adrenomedullin (ADM) is a 52-amino-acid peptide hormone first isolated from adrenal-medulla tumor tissue in 1993. Widely expressed and circulating, it promotes vasodilation, supports endothelial barrier integrity and helps regulate blood pressure. This page is educational and not medical advice.
Is Adrenomedullin an approved medicine?+
Adrenomedullin is discussed here as a research / educational topic. Cardiovascular, sepsis and biomarker research. This is not medical advice.
What is the typical length of Adrenomedullin?+
Adrenomedullin is commonly described as approximately 52 amino acids (Peptide hormone).