Page data last changed: . Chemistry registry snapshot: . Registry refreshes and identity assessments are separate from scientific content review.
A 52-residue vasodilatory hormone first isolated from a pheochromocytoma in 1993.
Also known as: ADM · AM
Part of the Foundational & therapeutic peptides cluster
Overview
Adrenomedullin (ADM) is a 52-amino-acid peptide hormone first isolated from adrenal-medulla tumor tissue in 1993. Widely expressed and circulating, it promotes vasodilation, supports endothelial barrier integrity and helps regulate blood pressure. This page is educational and not medical advice.
Source & context
Biological / chemical source: Encoded by the ADM gene; widely expressed and circulating
Primary research or clinical context: Cardiovascular, sepsis and biomarker research
Origin and signaling
ADM is cleaved from a 185-residue precursor and signals through calcitonin-receptor-like receptor (CLR) paired with RAMP2 or RAMP3 co-receptors. It is produced by endothelium, vascular smooth muscle and many other tissues, acting through cAMP and nitric-oxide pathways.
Research and biomarker use
Adrenomedullin and its stable surrogate MR-proADM are studied as markers of endothelial function and outcomes in heart failure and sepsis. Its vasodilatory, anti-inflammatory and tissue-protective actions make the ADM system a therapeutic-target candidate.
Structure & chemistry
Molecular identity & reference confidence
Source-supported reference
Reference values are taken from the cited molecular record or curated profile. A database match is not independent laboratory verification; modifications, counter-ions, and formulations can change the measured mass.
- Molecular form
- Adrenomedullin (source record; form not independently established)
- Species
- Not established by this molecular identity audit
- Termini (N / C)
- Not specified / Not specified
Average reference mass
Reference policy updated: 2026-10-05
- IUPHAR/BPS source snapshot · 2026-10-01
- PubChem molecular record · 2026-10-01
- Molecular formula
- C264H406N80O77S3
- Average reference mass
- ≈ 6,029
Chemistry values: PubChem, IUPHAR/BPS Guide to Pharmacology · fetched 2026-10-01.
Clinical development snapshot
ClinicalTrials.gov lists 34 registered studies with “Adrenomedullin” as an intervention (snapshot 2026-09-06). A registry footprint is not evidence of efficacy or approval.
| NCT | Title | Phase | Status | Updated |
|---|---|---|---|---|
| NCT07451769 | Selective Activation of the Adrenomedullin Receptors in Migraine | Not applicable | recruiting | 2026-08-28 |
| NCT02578810 | PIERS and BIS, sFIT:PIGF, Adrenomedullin | — | recruiting | 2026-04-23 |
| NCT04460963 | Role of Adrenomedullin in Leukemic Endosteal/Vascular Niches | Not applicable | active not recruiting | 2026-03-06 |
| NCT06130046 | MR-proADM as a Early Biomarker for DGF and AR in Kidney and Liver Transplantation | — | recruiting | 2025-08-01 |
| NCT07059546 | Hypersensitivity to Adrenomedullin in Post-Traumatic Headache | Not applicable | recruiting | 2025-07-30 |
| NCT04690660 | Swiss Postpartum Hypertension Cohort | — | recruiting | 2025-05-28 |
Adrenomedullin — reconstitution calculator
Enter how much peptide is in the vial and how much diluent (e.g. bacteriostatic water) is added. The tool returns the resulting solution concentration — and, for any amount you type, the volume it corresponds to. This is educational arithmetic, not a dosing recommendation.
Reference form: Adrenomedullin (source record; form not independently established)Average reference mass: 6,029 Da
Enter an amount to see the volume it corresponds to.
Educational concentration mathematics only. This tool does not recommend a dose, amount, or protocol, and nothing here is medical advice. Many peptides are not authorized by Health Canada for human use — see our reconstitution and bacteriostatic-water guides for context.
FAQ about Adrenomedullin
What is Adrenomedullin?+
Adrenomedullin (ADM) is a 52-amino-acid peptide hormone first isolated from adrenal-medulla tumor tissue in 1993. Widely expressed and circulating, it promotes vasodilation, supports endothelial barrier integrity and helps regulate blood pressure. This page is educational and not medical advice.
What Canadian product status is recorded for Adrenomedullin?+
Canadian product status for Adrenomedullin has not been verified in this profile. No verified record here does not mean no authorization exists. Status depends on the product, formulation and use; consult Health Canada's product records.
What is the typical length of Adrenomedullin?+
Adrenomedullin is commonly described as approximately 52 amino acids (Peptide hormone).
Related peptides
References & further reading
- 1.Cho et al. (2025). Endothelial insulin resistance induced by adrenomedullin mediates obesity-associated diabetes. Science
- 2.Mogi (2024). Effect of adrenomedullin on obesity-related hypertension. Hypertens Res
- 3.Udono-Fujimori et al. (2003). Adrenomedullin in the eye. Regul Pept
- 4.Yoshihara (2006). [Adrenomedullin]. Nihon Rinsho
- 5.Ajith Kumar (2020). Adrenomedullin in Sepsis: Finally, a Friend or an Enemy?. Indian J Crit Care Med
- 6.Li et al. (2020). Adrenomedullin: an important participant in neurological diseases. Neural Regen Res
- 7.Hinson et al. (2000). Adrenomedullin, a multifunctional regulatory peptide. Endocr Rev
- 8.Freed (2019). Healing the Broken Heart With Adrenomedullin. Circ Res
- 9.PMC — Adrenomedullin as a predictive marker of death and adverse events
- 10.Wikipedia — Adrenomedullin