The active pentapeptide fragment of thymopoietin — a compact model for thymic immune signaling.
Also known as: TP-5 · TP5
Part of the Repair & recovery peptides cluster
Overview
Thymopentin (TP-5, sequence RKDVY) is a synthetic pentapeptide corresponding to residues 32-36 of the thymic hormone thymopoietin. It interacts with T cells and has been studied as an immunomodulator, including historical immune-deficiency research. It is not authorized by Health Canada, though it is a registered medicine in some other countries.
Source & context
Biological / chemical source: Synthetic fragment of thymopoietin (residues 32-36)
Primary research or clinical context: Immunology research; approved as a medicine in some countries (not by Health Canada)
Fragment of thymopoietin
Thymopoietin is a thymic protein that affects T-cell differentiation. Researchers found that a short five-residue fragment, Arg-Lys-Asp-Val-Tyr, retained immune-signaling activity, and this fragment became thymopentin — a compact tool for studying thymic hormone action.
Research and status
Studies describe effects on T cells and monocytes via second-messenger signaling, and thymopentin has been used clinically for immune-deficiency indications in some jurisdictions. Its short half-life has limited broader development. This page is educational only.
Sequence
One-letter sequence commonly cited for Thymopentin (educational; isoforms and modifications may differ):
RKDVY
Residues plotted ~100° apart around an α-helix — clustering of one color reveals an amphipathic face.
FAQ about Thymopentin
What is Thymopentin?+
Thymopentin (TP-5, sequence RKDVY) is a synthetic pentapeptide corresponding to residues 32-36 of the thymic hormone thymopoietin. It interacts with T cells and has been studied as an immunomodulator, including historical immune-deficiency research. It is not authorized by Health Canada, though it is a registered medicine in some other countries.
Is Thymopentin an approved medicine?+
Thymopentin is discussed here as a research / educational topic. Immunology research; approved as a medicine in some countries (not by Health Canada). This is not medical advice.
What is the typical length of Thymopentin?+
Thymopentin is commonly described as approximately 5 amino acids (Immunomodulatory peptide).