Page data last changed: . Chemistry registry snapshot: . Registry refreshes and identity assessments are separate from scientific content review.
The active pentapeptide fragment of thymopoietin — a compact model for thymic immune signaling.
Also known as: TP-5 · TP5
Part of the Repair & recovery peptides cluster
Overview
Thymopentin (TP-5, sequence RKDVY) is a synthetic pentapeptide corresponding to residues 32-36 of the thymic hormone thymopoietin. It interacts with T cells and has been studied as an immunomodulator, including historical immune-deficiency research. It is not authorized by Health Canada, though it is a registered medicine in some other countries.
Source & context
Biological / chemical source: Synthetic fragment of thymopoietin (residues 32-36)
Primary research or clinical context: Immunology research; approved as a medicine in some countries (not by Health Canada)
Fragment of thymopoietin
Thymopoietin is a thymic protein that affects T-cell differentiation. Researchers found that a short five-residue fragment, Arg-Lys-Asp-Val-Tyr, retained immune-signaling activity, and this fragment became thymopentin — a compact tool for studying thymic hormone action.
Research and status
Studies describe effects on T cells and monocytes via second-messenger signaling, and thymopentin has been used clinically for immune-deficiency indications in some jurisdictions. Its short half-life has limited broader development. This page is educational only.
Sequence
One-letter sequence commonly cited for Thymopentin (educational; isoforms and modifications may differ):
RKDVY
Residues plotted ~100° apart around an α-helix — clustering of one color reveals an amphipathic face.
Structure & chemistry
Molecular identity & reference confidence
Source-supported reference
Reference values are taken from the cited molecular record or curated profile. A database match is not independent laboratory verification; modifications, counter-ions, and formulations can change the measured mass.
- Molecular form
- Thymopentin (source record; form not independently established)
- Species
- Not established by this molecular identity audit
- Termini (N / C)
- Not specified / Not specified
Average reference mass
Reference policy updated: 2026-10-05
- PubChem molecular record · 2026-10-01
- Molecular formula
- C30H49N9O9
- Average reference mass
- ≈ 679.8
- PubChem CID: 451417
- CAS RN: 69558-55-0
- UNII: O3Y80ZF13F
Chemistry values: PubChem · fetched 2026-10-01.
Clinical development snapshot
ClinicalTrials.gov lists 10 registered studies with “Thymopentin” as an intervention (snapshot 2026-10-01). A registry footprint is not evidence of efficacy or approval.
| NCT | Title | Phase | Status | Updated |
|---|---|---|---|---|
| NCT05978908 | Phase1 First in Human Ascending Dose Study to Evaluate the Safety and Tolerability of FC-12738 in Health Adult | Phase 1 | completed | 2025-05-25 |
| NCT06112041 | The Prospective Clinical Study of Precision PRaG Therapy in Elderly Patients With Advanced Solid Malignant Tum | Phase 2 | not yet recruiting | 2023-11-01 |
| NCT00460681 | Study of Thymopentin in Patients After Curative Resection of Small Hepatocellular Carcinoma | Phase 3 | unknown | 2007-10-31 |
| NCT00002066 | Double Blind Study of Thymopentin Effects on Patients With HIV-1 Infection | Not applicable | completed | 2005-06-24 |
| NCT00002051 | Double Blind Study of Thymopentin Effects on Patients With HIV-1 Infection | Not applicable | completed | 2005-06-24 |
| NCT00002109 | Double-Blind Study of Timunox (Thymopentin) in Asymptomatic HIV-Infected Patients Receiving Either Mono (AZT o | Phase 3 | completed | 2005-06-24 |
Thymopentin — reconstitution calculator
Enter how much peptide is in the vial and how much diluent (e.g. bacteriostatic water) is added. The tool returns the resulting solution concentration — and, for any amount you type, the volume it corresponds to. This is educational arithmetic, not a dosing recommendation.
Reference form: Thymopentin (source record; form not independently established)Average reference mass: 679.8 Da
Enter an amount to see the volume it corresponds to.
Educational concentration mathematics only. This tool does not recommend a dose, amount, or protocol, and nothing here is medical advice. Many peptides are not authorized by Health Canada for human use — see our reconstitution and bacteriostatic-water guides for context.
FAQ about Thymopentin
What is Thymopentin?+
Thymopentin (TP-5, sequence RKDVY) is a synthetic pentapeptide corresponding to residues 32-36 of the thymic hormone thymopoietin. It interacts with T cells and has been studied as an immunomodulator, including historical immune-deficiency research. It is not authorized by Health Canada, though it is a registered medicine in some other countries.
What Canadian product status is recorded for Thymopentin?+
Canadian product status for Thymopentin has not been verified in this profile. No verified record here does not mean no authorization exists. Status depends on the product, formulation and use; consult Health Canada's product records.
What is the typical length of Thymopentin?+
Thymopentin is commonly described as approximately 5 amino acids (Immunomodulatory peptide).
Related peptides
References & further reading
- 1.Haneke (1989). Thymopentin in dermatology. Curr Probl Dermatol
- 2.Friedmann (1985). Thymopentin: safety overview. Surv Immunol Res
- 3.Goldstein et al. (1985). Thymopoietin to thymopentin: experimental studies. Surv Immunol Res
- 4.Singh et al. (1998). Thymopentin and splenopentin as immunomodulators. Current status. Immunol Res
- 5.Kong et al. (2026). Thymopentin enhances adenoviral oncolytic therapy by regulating macrophages and CD8(+) T cells. Commun Med (Lond)
- 6.Bernengo et al. (1992). Thymopentin in Sézary syndrome. J Natl Cancer Inst
- 7.Sundal et al. (1994). Thymopentin treatment of rheumatoid arthritis. Arzneimittelforschung
- 8.Cao et al. (2023). Thymopentin ameliorates experimental colitis via inhibiting neutrophil extracellular traps. Int Immunopharmacol
- 9.PubMed — Thymopentin (TP5), an immunomodulatory peptide
- 10.Wikipedia — Thymopentin