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A fatty-acid-conjugated version of GHK designed for better skin-layer delivery in cosmetics.
Also known as: Pal-GHK · palmitoyl oligopeptide
Part of the Cosmetic & skin peptides cluster
Overview
Palmitoyl tripeptide-1 (Pal-GHK) is a lipidated cosmetic peptide made by attaching palmitic acid to the glycyl-histidyl-lysine (GHK) tripeptide. The palmitoyl chain increases lipophilicity, and it is discussed in cosmetic science alongside other matrikine peptides. It is presented here as a cosmetic ingredient.
Source & context
Biological / chemical source: Synthetic palmitoyl conjugate of the GHK tripeptide
Primary research or clinical context: Cosmetic ingredient in topical formulations
Why palmitoylation
The parent GHK tripeptide is a well-studied matrikine, but is hydrophilic. Adding a palmitoyl (C16) chain raises lipophilicity so the molecule interacts more readily with the skin's lipid barrier — a common formulation strategy for cosmetic peptides.
Cosmetic context
In cosmetic-science literature, palmitoyl tripeptide-1 is described as a fibroblast-signaling matrikine used in topical anti-aging formulas, often combined with palmitoyl tetrapeptide-7. This page frames it strictly as a cosmetic ingredient, not a therapeutic agent.
Sequence
One-letter sequence commonly cited for Palmitoyl Tripeptide-1 (educational; isoforms and modifications may differ):
GHK
Residues plotted ~100° apart around an α-helix — clustering of one color reveals an amphipathic face.
Structure & chemistry
Molecular identity & reference confidence
Source-supported reference
Reference values are taken from the cited molecular record or curated profile. A database match is not independent laboratory verification; modifications, counter-ions, and formulations can change the measured mass.
- Molecular form
- Palmitoyl Tripeptide-1 (source record; form not independently established)
- Species
- Not established by this molecular identity audit
- Termini (N / C)
- Not specified / Not specified
Average reference mass
Reference policy updated: 2026-10-05
- PubChem molecular record · 2026-10-01
- Molecular formula
- C30H54N6O5
- Average reference mass
- ≈ 578.8
- PubChem CID: 10231864
- CAS RN: 147732-56-7
- UNII: RV743D216M
Chemistry values: PubChem · fetched 2026-10-01.
Palmitoyl Tripeptide-1 — reconstitution calculator
Enter how much peptide is in the vial and how much diluent (e.g. bacteriostatic water) is added. The tool returns the resulting solution concentration — and, for any amount you type, the volume it corresponds to. This is educational arithmetic, not a dosing recommendation.
Reference form: Palmitoyl Tripeptide-1 (source record; form not independently established)Average reference mass: 578.8 Da
Enter an amount to see the volume it corresponds to.
Educational concentration mathematics only. This tool does not recommend a dose, amount, or protocol, and nothing here is medical advice. Many peptides are not authorized by Health Canada for human use — see our reconstitution and bacteriostatic-water guides for context.
FAQ about Palmitoyl Tripeptide-1
What is Palmitoyl Tripeptide-1?+
Palmitoyl tripeptide-1 (Pal-GHK) is a lipidated cosmetic peptide made by attaching palmitic acid to the glycyl-histidyl-lysine (GHK) tripeptide. The palmitoyl chain increases lipophilicity, and it is discussed in cosmetic science alongside other matrikine peptides. It is presented here as a cosmetic ingredient.
What Canadian product status is recorded for Palmitoyl Tripeptide-1?+
Canadian product status for Palmitoyl Tripeptide-1 has not been verified in this profile. No verified record here does not mean no authorization exists. Status depends on the product, formulation and use; consult Health Canada's product records.
What is the typical length of Palmitoyl Tripeptide-1?+
Palmitoyl Tripeptide-1 is commonly described as approximately 3 amino acids (Cosmetic ingredient peptide).