Peptides Codex
ENFR
← Home
Cosmetic signal peptide (INCI ingredient)

Palmitoyl Tetrapeptide-7

Palmitoyl Tetrapeptide-7 (Pal-GQPR) is a lipidated cosmetic peptide based on a Gly-Gln-Pro-Arg fragment of immunoglobulin G, and a component of the Matrixyl 3000 complex. In cosmetic use it is associated with the appearance of firmer skin. This page describes it as a cosmetic ingredient and makes no medical claim.

By The Peptides Codex Editorial TeamReviewed July 10, 2026
Length
4 aa
Class
Cosmetic signal peptide (INCI ingredient)
Function
Cosmetic-ingredient peptide associated with the look of skin firmness and calming of visible signs of stress
Context
Cosmetic ingredient (INCI: Palmitoyl Tetrapeptide-7), a component of the Matrixyl 3000 complex; framed as a cosmetic ingredient, not a drug

One of the two peptides in the widely marketed Matrixyl 3000 anti-aging complex.

Also known as: Pal-GQPR

Part of the Cosmetic & skin peptides cluster

Overview

Palmitoyl Tetrapeptide-7 (Pal-GQPR) is a lipidated cosmetic peptide based on a Gly-Gln-Pro-Arg fragment of immunoglobulin G, and a component of the Matrixyl 3000 complex. In cosmetic use it is associated with the appearance of firmer skin. This page describes it as a cosmetic ingredient and makes no medical claim.

Source & context

Biological / chemical source: Synthetic tetrapeptide (Gly-Gln-Pro-Arg fragment) conjugated to a palmitoyl chain

Primary research or clinical context: Cosmetic ingredient (INCI: Palmitoyl Tetrapeptide-7), a component of the Matrixyl 3000 complex; framed as a cosmetic ingredient, not a drug

Design and pairing

The peptide couples the sequence Gly-Gln-Pro-Arg to a palmitoyl lipid chain, which improves compatibility with skin-care formulations. It is most familiar as one half of Matrixyl 3000, where it is paired with Palmitoyl Tripeptide-1. In cosmetic literature it is associated with modulating the skin's response to visible signs of environmental stress.

Cosmetic framing

As a topical cosmetic ingredient, Palmitoyl Tetrapeptide-7 is discussed in terms of the appearance of firmness and fine lines rather than any physiological treatment effect. In Canada it is used within cosmetic products under its INCI name. This page is educational and does not claim the ingredient treats or cures any skin condition.

FAQ about Palmitoyl Tetrapeptide-7

What is Palmitoyl Tetrapeptide-7?+

Palmitoyl Tetrapeptide-7 (Pal-GQPR) is a lipidated cosmetic peptide based on a Gly-Gln-Pro-Arg fragment of immunoglobulin G, and a component of the Matrixyl 3000 complex. In cosmetic use it is associated with the appearance of firmer skin. This page describes it as a cosmetic ingredient and makes no medical claim.

Is Palmitoyl Tetrapeptide-7 an approved medicine?+

Palmitoyl Tetrapeptide-7 is discussed here as a research / educational topic. Cosmetic ingredient (INCI: Palmitoyl Tetrapeptide-7), a component of the Matrixyl 3000 complex; framed as a cosmetic ingredient, not a drug. This is not medical advice.

What is the typical length of Palmitoyl Tetrapeptide-7?+

Palmitoyl Tetrapeptide-7 is commonly described as approximately 4 amino acids (Cosmetic signal peptide (INCI ingredient)).

Related peptides

Secretin
Hormone
Secretin is a 27-amino-acid hormone released from duodenal S-cells in response to stomach acid entering the small intestine. Discovered by Bayliss and Starling in 1902, it was the first substance ever called a hormone and remains a landmark in the history of endocrinology.
Gastrin
Gut hormone
Gastrin is a peptide hormone released by G-cells of the gastric antrum that stimulates acid secretion from the stomach's parietal cells. Circulating in several lengths such as gastrin-17 and gastrin-34, it is a foundational hormone in digestive physiology and in the study of acid-related disorders.
Efpeglenatide
Incretin mimetic (GLP-1 receptor agonist)
Efpeglenatide is a long-acting GLP-1 receptor agonist built from an exendin-based peptide conjugated to an antibody Fc fragment for extended duration. It has been evaluated in large clinical programs, including the AMPLITUDE-O cardiovascular-outcomes trial, and remains investigational — it is not authorized by Health Canada.
Galanin
Neuropeptide
Galanin is a neuropeptide (30 residues in humans) that modulates neurotransmission across many brain regions. Research explores its involvement in mood, feeding, and pain-signaling pathways.

References & further reading

  1. 1.Wikipedia — Palmitoyl tetrapeptide-7
  2. 2.INCIDecoder — Palmitoyl Tetrapeptide-7
Disclaimer: Educational content only. Not medical advice. Not instructions for human use. Research peptides and unapproved products may be restricted or illegal to market for human consumption in your jurisdiction. Consult qualified professionals and applicable law.
You might also like: All peptides · Atlas · Research · Tools
Cite this: Peptides Codex — Palmitoyl Tetrapeptide-7 educational profile.
Tip: Use browser print (Ctrl/Cmd + P) for a clean PDF of this page.