Page data last changed: . Chemistry registry snapshot: . Registry refreshes and identity assessments are separate from scientific content review.
One of the two peptides in the widely marketed Matrixyl 3000 anti-aging complex.
Also known as: Pal-GQPR
Part of the Cosmetic & skin peptides cluster
Overview
Palmitoyl Tetrapeptide-7 (Pal-GQPR) is a lipidated cosmetic peptide based on a Gly-Gln-Pro-Arg fragment of immunoglobulin G, and a component of the Matrixyl 3000 complex. In cosmetic use it is associated with the appearance of firmer skin. This page describes it as a cosmetic ingredient and makes no medical claim.
Source & context
Biological / chemical source: Synthetic tetrapeptide (Gly-Gln-Pro-Arg fragment) conjugated to a palmitoyl chain
Primary research or clinical context: Cosmetic ingredient (INCI: Palmitoyl Tetrapeptide-7), a component of the Matrixyl 3000 complex; framed as a cosmetic ingredient, not a drug
Design and pairing
The peptide couples the sequence Gly-Gln-Pro-Arg to a palmitoyl lipid chain, which improves compatibility with skin-care formulations. It is most familiar as one half of Matrixyl 3000, where it is paired with Palmitoyl Tripeptide-1. In cosmetic literature it is associated with modulating the skin's response to visible signs of environmental stress.
Cosmetic framing
As a topical cosmetic ingredient, Palmitoyl Tetrapeptide-7 is discussed in terms of the appearance of firmness and fine lines rather than any physiological treatment effect. In Canada it is used within cosmetic products under its INCI name. This page is educational and does not claim the ingredient treats or cures any skin condition.
Structure & chemistry
Molecular identity & reference confidence
Source-supported reference
Reference values are taken from the cited molecular record or curated profile. A database match is not independent laboratory verification; modifications, counter-ions, and formulations can change the measured mass.
- Molecular form
- Palmitoyl Tetrapeptide-7 (source record; form not independently established)
- Species
- Not established by this molecular identity audit
- Termini (N / C)
- Not specified / Not specified
Average reference mass
Reference policy updated: 2026-10-05
- PubChem molecular record · 2026-10-01
- Molecular formula
- C34H62N8O7
- Average reference mass
- ≈ 694.9
- PubChem CID: 10078408
- CAS RN: 221227-05-0
- UNII: Q41S464P1R
Chemistry values: PubChem · fetched 2026-10-01.
Clinical development snapshot
ClinicalTrials.gov lists 1 registered study with “Palmitoyl Tetrapeptide-7” as an intervention (snapshot 2026-09-06). A registry footprint is not evidence of efficacy or approval.
| NCT | Title | Phase | Status | Updated |
|---|---|---|---|---|
| NCT05932732 | Trial Assessing the Impact on Facial Skin Quality, Hydration, and Skin Barrier of Three (3) Hydrafacial Treatm | Phase 4 | completed | 2024-10-24 |
Palmitoyl Tetrapeptide-7 — reconstitution calculator
Enter how much peptide is in the vial and how much diluent (e.g. bacteriostatic water) is added. The tool returns the resulting solution concentration — and, for any amount you type, the volume it corresponds to. This is educational arithmetic, not a dosing recommendation.
Reference form: Palmitoyl Tetrapeptide-7 (source record; form not independently established)Average reference mass: 694.9 Da
Enter an amount to see the volume it corresponds to.
Educational concentration mathematics only. This tool does not recommend a dose, amount, or protocol, and nothing here is medical advice. Many peptides are not authorized by Health Canada for human use — see our reconstitution and bacteriostatic-water guides for context.
FAQ about Palmitoyl Tetrapeptide-7
What is Palmitoyl Tetrapeptide-7?+
Palmitoyl Tetrapeptide-7 (Pal-GQPR) is a lipidated cosmetic peptide based on a Gly-Gln-Pro-Arg fragment of immunoglobulin G, and a component of the Matrixyl 3000 complex. In cosmetic use it is associated with the appearance of firmer skin. This page describes it as a cosmetic ingredient and makes no medical claim.
What Canadian product status is recorded for Palmitoyl Tetrapeptide-7?+
Canadian product status for Palmitoyl Tetrapeptide-7 has not been verified in this profile. No verified record here does not mean no authorization exists. Status depends on the product, formulation and use; consult Health Canada's product records.
What is the typical length of Palmitoyl Tetrapeptide-7?+
Palmitoyl Tetrapeptide-7 is commonly described as approximately 4 amino acids (Cosmetic signal peptide (INCI ingredient)).
Related peptides
References & further reading
- 1.Ashish et al. (2002). Folded conformation of an immunostimulating tetrapeptide rigin: high temperature molecular dynamics simulation study. Bioorg Med Chem
- 2.Kumar et al. (2010). Determination of an unusual secondary structural element in the immunostimulating tetrapeptide rigin in aqueous environments: insights via MD simulations, (1)H NMR and CD spectroscopic studies. J Pept Sci
- 3.Ashish et al. (2000). Characterization of a novel type VII beta-turn conformation for a bio-active tetrapeptide rigin A synergy between theoretical and experimental results. Eur J Biochem
- 4.INCIDecoder — Palmitoyl Tetrapeptide-7
- 5.Wikipedia — Palmitoyl tetrapeptide-7