Skip to content
Peptides Codex
ENFR

Use the arrow keys to choose a result, Enter to open it, and Escape to close.

← Home
Synthetic tetrapeptide bioregulator (Khavinson class)

Cardiogen

Cardiogen (Ala-Glu-Asp-Arg, AEDR) is a synthetic tetrapeptide from the Khavinson family of bioregulators, studied as a heart-tissue peptide in cardiac gene-expression research.

By The Peptides Codex Editorial TeamIndividual review date not recorded

Page data last changed: . Registry refreshes and identity assessments are separate from scientific content review.

Length
4 aa
Class
Synthetic tetrapeptide bioregulator (Khavinson class)
Function
Short synthetic peptide studied as a heart-tissue bioregulator in cardiac gene-expression research
Context
Investigational bioregulator studied in Russian cardiology and aging research; not authorized by Health Canada

A defined four-residue peptide patented as a myocardium-directed bioregulator.

Also known as: AEDR peptide · Ala-Glu-Asp-Arg

Part of the Neuropeptides & signaling cluster

Overview

Cardiogen (Ala-Glu-Asp-Arg, AEDR) is a synthetic tetrapeptide from the Khavinson family of bioregulators, studied as a heart-tissue peptide in cardiac gene-expression research. It is the subject of a patent describing a myocardium-directed peptide. It is not authorized by Health Canada, and this page is educational only.

Source & context

Biological / chemical source: Synthetic tetrapeptide developed at the St. Petersburg Institute of Bioregulation and Gerontology

Primary research or clinical context: Investigational bioregulator studied in Russian cardiology and aging research; not authorized by Health Canada

A tissue-directed tetrapeptide

Cardiogen is the four-residue sequence Ala-Glu-Asp-Arg, developed within the Khavinson bioregulator program and patented as a peptide substance intended to support myocardial function. The underlying hypothesis is that short, tissue-associated sequences can influence tissue-specific gene expression — a framework applied across the cardiogen, cortagen and thymogen family.

Evidence and regulatory status

Reported experiments come largely from Russian institutes and preclinical models, with limited independent Western replication of cardiac-specific effects. Cardiogen is investigational, sold for research use only, and is not authorized by Health Canada. This page describes its chemistry and research context for education only and makes no therapeutic claim.

Sequence

One-letter sequence commonly cited for Cardiogen (educational; isoforms and modifications may differ):

AEDR

AEDR

Cardiogen4 aaPEPTIDESCODEX.COMN-terminus →→ C-terminusA1E−2D−3R+4nonpolarpolaracidicbasicGly / Pronon-canonical (X)Hydropathy (Kyte–Doolittle): ▮ hydrophobic (cyan) / ▮ hydrophilic (rose) · Side-chain charge at pH 7: + / −
Cardiogen — Structure cardDownload SVG
A1E2D3R4
Helical wheel projection

Residues plotted ~100° apart around an α-helix — clustering of one color reveals an amphipathic face.

Analyze sequences in the playground →

Structure & chemistry

Molecular identity & reference confidence

Reference mass unavailable

Reference values are taken from the cited molecular record or curated profile. A database match is not independent laboratory verification; modifications, counter-ions, and formulations can change the measured mass.

Molecular form
Cardiogen (source record; form not independently established)
Species
Not established by this molecular identity audit
Termini (N / C)
Not specified / Not specified

Average reference mass

Reference policy updated: 2026-10-05

Clinical development snapshot

ClinicalTrials.gov lists 1 registered study with “Cardiogen” as an intervention (snapshot 2026-09-06). A registry footprint is not evidence of efficacy or approval.

Registered studies
1
Highest phase reached
—
Active in latest 100
0
Most recent update
2012-08-15
Most recently updated studies
NCTTitlePhaseStatusUpdated
NCT01424774Prospective Evaluation of Strontium in Patients After CardioGen-82 PET MPI Scanning—completed2012-08-15
See all on ClinicalTrials.gov →

FAQ about Cardiogen

What is Cardiogen?+

Cardiogen (Ala-Glu-Asp-Arg, AEDR) is a synthetic tetrapeptide from the Khavinson family of bioregulators, studied as a heart-tissue peptide in cardiac gene-expression research. It is the subject of a patent describing a myocardium-directed peptide. It is not authorized by Health Canada, and this page is educational only.

What Canadian product status is recorded for Cardiogen?+

Canadian product status for Cardiogen has not been verified in this profile. No verified record here does not mean no authorization exists. Status depends on the product, formulation and use; consult Health Canada's product records.

What is the typical length of Cardiogen?+

Cardiogen is commonly described as approximately 4 amino acids (Synthetic tetrapeptide bioregulator (Khavinson class)).

Related peptides

Plectasin
Fungal defensin antimicrobial peptide
Plectasin is a 40-amino-acid antimicrobial peptide from the saprophytic fungus Pseudoplectania nigrella, and the first defensin discovered in a fungus. It kills Gram-positive bacteria, including antibiotic-resistant Streptococcus pneumoniae, by binding the cell-wall precursor lipid II rather than by lysing membranes, and it can be produced recombinantly at high yield. This page is educational and not medical advice.
BPC-157
Research pentadecapeptide (gastric-juice-derived sequence)
BPC-157 (Body Protection Compound-157) is a synthetic 15-residue peptide, GEPPPGKPADDAGLV, derived from a sequence found in human gastric juice. Hundreds of rodent studies, most from a single Zagreb group, report accelerated healing of tendon, muscle, ligament, gut and skin injuries via VEGFR2, nitric-oxide and ERK1/2 pathways. Human evidence is limited to a small safety study and a retrospective chart review; the first phase 2 efficacy trial began recruiting in 2026. It is not approved anywhere and the FDA barred it from compounding in 2023.
TB-500
Synthetic thymosin β4 fragment (research peptide)
TB-500 is the synthetic, N-acetylated heptapeptide Ac-Leu-Lys-Lys-Thr-Glu-Thr-Gln (Ac-LKKTETQ), corresponding to residues 17–23 of thymosin β4, the protein's actin-binding motif. It first appeared as a veterinary preparation and is sold as a research chemical; its metabolism has been characterised in rats. A 2026 rat tendon study reported benefits with vendor-labelled TB-500 whose sequence was not characterized, so it does not establish efficacy of Ac-LKKTETQ. The fragment has no published human efficacy data. No product-specific authorization record has been verified in this profile; human trial registration does not establish approval. Its first registered human trial began recruiting in 2026.
Tirzepatide
Incretin dual agonist
Tirzepatide is a 39-amino-acid synthetic peptide (C225H348N48O68, ≈4,814 Da) that activates both the GIP and GLP-1 receptors. Its backbone is derived from GIP, with an exendin-4-like C-terminal tail, Aib residues at positions 2 and 13, and a C20 fatty diacid on Lys20 that binds albumin for a half-life of about 5 days. Approved as Mounjaro (type 2 diabetes, 2022) and Zepbound (weight management, 2023; obstructive sleep apnoea, 2024).

References & further reading

  1. 1.Levdik et al. (2009). Tumor-modifying effect of cardiogen peptide on M-1 sarcoma in senescent rats. Bull Exp Biol Med
  2. 2.Chalisova et al. (2009). [The effect of the amino acids and cardiogen on the development of myocard tissue culture from young and old rats]. Adv Gerontol
  3. 3.Blazsó et al. (2017). [Cardiomyopathy and ion channel diseases registry: the Szeged CardioGen Registry]. Orv Hetil
  4. 4.Google Patents — US7662789B2 Peptide substance restoring myocardium function (Ala-Glu-Asp-Arg)
  5. 5.PMC — Peptides as epigenetic modulators: therapeutic implications (Khavinson peptides review)
Disclaimer: Educational content only. Not medical advice. Not instructions for human use. Research peptides and unapproved products may be restricted or illegal to market for human consumption in your jurisdiction. Consult qualified professionals and applicable law.
You might also like: All peptides · Atlas · Research · Tools
Cite this: Peptides Codex — Cardiogen educational profile.
Tip: Use browser print (Ctrl/Cmd + P) for a clean PDF of this page.