A defined four-residue peptide patented as a myocardium-directed bioregulator.
Also known as: AEDR peptide · Ala-Glu-Asp-Arg
Part of the Neuropeptides & signaling cluster
Overview
Cardiogen (Ala-Glu-Asp-Arg, AEDR) is a synthetic tetrapeptide from the Khavinson family of bioregulators, studied as a heart-tissue peptide in cardiac gene-expression research. It is the subject of a patent describing a myocardium-directed peptide. It is not authorized by Health Canada, and this page is educational only.
Source & context
Biological / chemical source: Synthetic tetrapeptide developed at the St. Petersburg Institute of Bioregulation and Gerontology
Primary research or clinical context: Investigational bioregulator studied in Russian cardiology and aging research; not authorized by Health Canada
A tissue-directed tetrapeptide
Cardiogen is the four-residue sequence Ala-Glu-Asp-Arg, developed within the Khavinson bioregulator program and patented as a peptide substance intended to support myocardial function. The underlying hypothesis is that short, tissue-associated sequences can influence tissue-specific gene expression — a framework applied across the cardiogen, cortagen and thymogen family.
Evidence and regulatory status
Reported experiments come largely from Russian institutes and preclinical models, with limited independent Western replication of cardiac-specific effects. Cardiogen is investigational, sold for research use only, and is not authorized by Health Canada. This page describes its chemistry and research context for education only and makes no therapeutic claim.
Sequence
One-letter sequence commonly cited for Cardiogen (educational; isoforms and modifications may differ):
AEDR
Residues plotted ~100° apart around an α-helix — clustering of one color reveals an amphipathic face.
FAQ about Cardiogen
What is Cardiogen?+
Cardiogen (Ala-Glu-Asp-Arg, AEDR) is a synthetic tetrapeptide from the Khavinson family of bioregulators, studied as a heart-tissue peptide in cardiac gene-expression research. It is the subject of a patent describing a myocardium-directed peptide. It is not authorized by Health Canada, and this page is educational only.
Is Cardiogen an approved medicine?+
Cardiogen is discussed here as a research / educational topic. Investigational bioregulator studied in Russian cardiology and aging research; not authorized by Health Canada. This is not medical advice.
What is the typical length of Cardiogen?+
Cardiogen is commonly described as approximately 4 amino acids (Synthetic tetrapeptide bioregulator (Khavinson class)).