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Oxytocin analog

Carbetocin

Carbetocin is a synthetic long-acting analog of oxytocin.

By The Peptides Codex Editorial TeamIndividual review date not recorded

Page data last changed: . Chemistry registry snapshot: . Registry refreshes and identity assessments are separate from scientific content review.

Length
8 aa
Class
Oxytocin analog
Function
Oxytocin receptor agonist (long-acting)
Context
Approved to prevent postpartum hemorrhage

A long-acting oxytocin analog given as a single dose after delivery.

Also known as: Duratocin · Pabal

Part of the Foundational & therapeutic peptides cluster

Overview

Carbetocin is a synthetic long-acting analog of oxytocin. Structural modifications extend its half-life to roughly 85-100 minutes versus a few minutes for oxytocin, allowing a single dose to sustain uterine contraction, and it is an approved therapeutic for preventing postpartum hemorrhage. This page is educational and not medical advice.

Source & context

Biological / chemical source: Synthetic octapeptide analog of oxytocin

Primary research or clinical context: Approved to prevent postpartum hemorrhage

Durability engineering

Deamination and a thioether substitution replace the disulfide bridge of oxytocin, protecting the peptide from rapid breakdown. The much longer half-life is why one dose can maintain uterine tone, a practical illustration of half-life extension in peptide design.

Uterotonic action

By activating uterine oxytocin receptors, carbetocin drives sustained contraction that reduces bleeding after delivery. A heat-stable formulation broadened its use in settings without reliable refrigeration, making it a notable global-health peptide.

Structure & chemistry

Molecular identity & reference confidence

Source-supported reference

Reference values are taken from the cited molecular record or curated profile. A database match is not independent laboratory verification; modifications, counter-ions, and formulations can change the measured mass.

Molecular form
Carbetocin (source record; form not independently established)
Species
Not established by this molecular identity audit
Termini (N / C)
Not specified / Not specified

Average reference mass

Reference policy updated: 2026-10-05

Molecular formula
C45H69N11O12S
Average reference mass
≈ 988.2
Status
Approved medicine in at least one jurisdiction (IUPHAR record)
Identifiers

Chemistry values: PubChem, IUPHAR/BPS Guide to Pharmacology · fetched 2026-10-01.

Clinical development snapshot

ClinicalTrials.gov lists 103 registered studies with “Carbetocin” as an intervention (snapshot 2026-09-06). A registry footprint is not evidence of efficacy or approval.

Registered studies
103
Highest phase reached
Phase 4
Active in latest 100
16
Most recent update
2026-08-17
Most recently updated studies
NCTTitlePhaseStatusUpdated
NCT06420297OLE Study of Carbetocin Nasal Spray for the Treatment of Hyperphagia in Prader-Willi SyndromePhase 3terminated2026-08-17
NCT07721623The Efficacy of Carbitocin in Reduction of Blood Loss During MyomectomyEarly phase 1not yet recruiting2026-07-23
NCT07636421Carbetocin Monotherapy Versus Carbetocin Plus Oxytocin Infusion in Elective Cesarean Delivery: A Non-InferioriPhase 4not yet recruiting2026-06-09
NCT07401524Carbetocin Uterotonic Treatment in Twin Pregnancies for Prevention of Postpartum HemorrhagePhase 4recruiting2026-05-08
NCT06285409Comparing the Dose-response Profiles of Uterotonics After Initial Carbetocin Administration - an Ex-vivo StudyNot applicablerecruiting2026-04-06
NCT07187544Effect of Co-administration of Carbetocin and Calcium Chloride on Uterine Tone in Patients Undergoing ElectiveNot applicablerecruiting2026-04-01
See all on ClinicalTrials.gov →
Concentration math

Carbetocin — reconstitution calculator

Enter how much peptide is in the vial and how much diluent (e.g. bacteriostatic water) is added. The tool returns the resulting solution concentration — and, for any amount you type, the volume it corresponds to. This is educational arithmetic, not a dosing recommendation.

Reference form: Carbetocin (source record; form not independently established)Average reference mass: 988.2 Da

Syringe graduation
Solution concentration
5 mg/mL5,000 mcg/mL
mcg

Enter an amount to see the volume it corresponds to.

Educational concentration mathematics only. This tool does not recommend a dose, amount, or protocol, and nothing here is medical advice. Many peptides are not authorized by Health Canada for human use — see our reconstitution and bacteriostatic-water guides for context.

Open the Carbetocin calculator on its own page →

FAQ about Carbetocin

What is Carbetocin?+

Carbetocin is a synthetic long-acting analog of oxytocin. Structural modifications extend its half-life to roughly 85-100 minutes versus a few minutes for oxytocin, allowing a single dose to sustain uterine contraction, and it is an approved therapeutic for preventing postpartum hemorrhage. This page is educational and not medical advice.

What Canadian product status is recorded for Carbetocin?+

Canadian product status for Carbetocin has not been verified in this profile. No verified record here does not mean no authorization exists. Status depends on the product, formulation and use; consult Health Canada's product records.

What is the typical length of Carbetocin?+

Carbetocin is commonly described as approximately 8 amino acids (Oxytocin analog).

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References & further reading

  1. 1.Wang (2018). Postpartum hemorrhage: A value of carbetocin. Taiwan J Obstet Gynecol
  2. 2.Roof et al. (2023). Intranasal Carbetocin Reduces Hyperphagia, Anxiousness, and Distress in Prader-Willi Syndrome: CARE-PWS Phase 3 Trial. J Clin Endocrinol Metab
  3. 3.Su et al. (2012). Carbetocin for preventing postpartum haemorrhage. Cochrane Database Syst Rev
  4. 4.Maged et al. (2016). Carbetocin versus oxytocin in the management of atonic post partum haemorrhage (PPH) after vaginal delivery: a randomised controlled trial. Arch Gynecol Obstet
  5. 5.Gallos et al. (2019). Carbetocin: Worth the extra expense?. Best Pract Res Clin Obstet Gynaecol
  6. 6.Bekkenes et al. (2025). Effects of Prophylactic Oxytocin or Carbetocin on Troponin Release and Postpartum Haemorrhage at Planned Caesarean Delivery: A Double-Blind Randomised Controlled Trial. BJOG
  7. 7.Huang et al. (2022). Effect of Carbetocin on Postpartum Hemorrhage after Vaginal Delivery: A Meta-Analysis. Comput Math Methods Med
  8. 8.Engstrøm et al. (1998). Oxytocin receptor binding and uterotonic activity of carbetocin and its metabolites following enzymatic degradation. Eur J Pharmacol
  9. 9.PubChem — compound summary for Carbetocin (CID 16681432)
  10. 10.Wikipedia — Carbetocin
Disclaimer: Educational content only. Not medical advice. Not instructions for human use. Research peptides and unapproved products may be restricted or illegal to market for human consumption in your jurisdiction. Consult qualified professionals and applicable law.
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