Page data last changed: . Chemistry registry snapshot: . Registry refreshes and identity assessments are separate from scientific content review.
Best known by the trade name Eyeseryl, formulated for the appearance of eye bags.
Also known as: Eyeseryl
Part of the Cosmetic & skin peptides cluster
Overview
Acetyl Tetrapeptide-5 (trade name Eyeseryl) is a synthetic acetylated tetrapeptide used as a cosmetic ingredient in eye-care products, marketed for the appearance of under-eye puffiness. This page describes it as a cosmetic ingredient for educational purposes and makes no drug or medical claim.
Source & context
Biological / chemical source: Synthetic acetylated tetrapeptide
Primary research or clinical context: Cosmetic ingredient (INCI: Acetyl Tetrapeptide-5), used topically in eye-care formulations; framed as a cosmetic ingredient, not a drug
How it is positioned
Acetyl Tetrapeptide-5 has the structure Ac-βAla-His-Ser-His and appears on labels under the INCI name Acetyl Tetrapeptide-5 or the trade name Eyeseryl. In cosmetic marketing it is associated with reducing the visible appearance of eye bags, typically attributed to effects on the look of fluid retention and skin firmness around the eye.
Evidence and framing
Much of the supporting data is supplier-provided, and independent reviews note a shortage of robust third-party clinical trials. In Canada, peptides like this are used within cosmetic products and are described in terms of appearance, not treatment. This page is educational and does not claim the ingredient treats, cures or prevents any condition.
Structure & chemistry
Molecular identity & reference confidence
Source-supported reference
Reference values are taken from the cited molecular record or curated profile. A database match is not independent laboratory verification; modifications, counter-ions, and formulations can change the measured mass.
- Molecular form
- Acetyl Tetrapeptide-5 (source record; form not independently established)
- Species
- Not established by this molecular identity audit
- Termini (N / C)
- Not specified / Not specified
Average reference mass
Reference policy updated: 2026-10-05
- PubChem molecular record · 2026-10-01
- Molecular formula
- C20H28N8O7
- Average reference mass
- ≈ 492.5
- PubChem CID: 11620163
- CAS RN: 820959-17-9
- UNII: Y1DFQ308G8
Chemistry values: PubChem · fetched 2026-10-01.
Acetyl Tetrapeptide-5 — reconstitution calculator
Enter how much peptide is in the vial and how much diluent (e.g. bacteriostatic water) is added. The tool returns the resulting solution concentration — and, for any amount you type, the volume it corresponds to. This is educational arithmetic, not a dosing recommendation.
Reference form: Acetyl Tetrapeptide-5 (source record; form not independently established)Average reference mass: 492.5 Da
Enter an amount to see the volume it corresponds to.
Educational concentration mathematics only. This tool does not recommend a dose, amount, or protocol, and nothing here is medical advice. Many peptides are not authorized by Health Canada for human use — see our reconstitution and bacteriostatic-water guides for context.
FAQ about Acetyl Tetrapeptide-5
What is Acetyl Tetrapeptide-5?+
Acetyl Tetrapeptide-5 (trade name Eyeseryl) is a synthetic acetylated tetrapeptide used as a cosmetic ingredient in eye-care products, marketed for the appearance of under-eye puffiness. This page describes it as a cosmetic ingredient for educational purposes and makes no drug or medical claim.
What Canadian product status is recorded for Acetyl Tetrapeptide-5?+
Canadian product status for Acetyl Tetrapeptide-5 has not been verified in this profile. No verified record here does not mean no authorization exists. Status depends on the product, formulation and use; consult Health Canada's product records.
What is the typical length of Acetyl Tetrapeptide-5?+
Acetyl Tetrapeptide-5 is commonly described as approximately 4 amino acids (Cosmetic signal peptide (INCI ingredient)).