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Cosmetic signal peptide (INCI ingredient)

Acetyl Tetrapeptide-5

Acetyl Tetrapeptide-5 (trade name Eyeseryl) is a synthetic acetylated tetrapeptide used as a cosmetic ingredient in eye-care products, marketed for the appearance of under-eye puffiness. This page describes it as a cosmetic ingredient for educational purposes and makes no drug or medical claim.

By The Peptides Codex Editorial TeamReviewed July 10, 2026
Length
4 aa
Class
Cosmetic signal peptide (INCI ingredient)
Function
Cosmetic-ingredient peptide marketed for the look of under-eye puffiness and skin firmness
Context
Cosmetic ingredient (INCI: Acetyl Tetrapeptide-5), used topically in eye-care formulations; framed as a cosmetic ingredient, not a drug

Best known by the trade name Eyeseryl, formulated for the appearance of eye bags.

Also known as: Eyeseryl

Part of the Cosmetic & skin peptides cluster

Overview

Acetyl Tetrapeptide-5 (trade name Eyeseryl) is a synthetic acetylated tetrapeptide used as a cosmetic ingredient in eye-care products, marketed for the appearance of under-eye puffiness. This page describes it as a cosmetic ingredient for educational purposes and makes no drug or medical claim.

Source & context

Biological / chemical source: Synthetic acetylated tetrapeptide

Primary research or clinical context: Cosmetic ingredient (INCI: Acetyl Tetrapeptide-5), used topically in eye-care formulations; framed as a cosmetic ingredient, not a drug

How it is positioned

Acetyl Tetrapeptide-5 has the structure Ac-βAla-His-Ser-His and appears on labels under the INCI name Acetyl Tetrapeptide-5 or the trade name Eyeseryl. In cosmetic marketing it is associated with reducing the visible appearance of eye bags, typically attributed to effects on the look of fluid retention and skin firmness around the eye.

Evidence and framing

Much of the supporting data is supplier-provided, and independent reviews note a shortage of robust third-party clinical trials. In Canada, peptides like this are used within cosmetic products and are described in terms of appearance, not treatment. This page is educational and does not claim the ingredient treats, cures or prevents any condition.

FAQ about Acetyl Tetrapeptide-5

What is Acetyl Tetrapeptide-5?+

Acetyl Tetrapeptide-5 (trade name Eyeseryl) is a synthetic acetylated tetrapeptide used as a cosmetic ingredient in eye-care products, marketed for the appearance of under-eye puffiness. This page describes it as a cosmetic ingredient for educational purposes and makes no drug or medical claim.

Is Acetyl Tetrapeptide-5 an approved medicine?+

Acetyl Tetrapeptide-5 is discussed here as a research / educational topic. Cosmetic ingredient (INCI: Acetyl Tetrapeptide-5), used topically in eye-care formulations; framed as a cosmetic ingredient, not a drug. This is not medical advice.

What is the typical length of Acetyl Tetrapeptide-5?+

Acetyl Tetrapeptide-5 is commonly described as approximately 4 amino acids (Cosmetic signal peptide (INCI ingredient)).

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References & further reading

  1. 1.INCIDecoder — Acetyl Tetrapeptide-5
  2. 2.SpecialChem — Acetyl Tetrapeptide-5 (INCI ingredient profile)
Disclaimer: Educational content only. Not medical advice. Not instructions for human use. Research peptides and unapproved products may be restricted or illegal to market for human consumption in your jurisdiction. Consult qualified professionals and applicable law.
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Cite this: Peptides Codex — Acetyl Tetrapeptide-5 educational profile.
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