Page data last changed: . Chemistry registry snapshot: . Registry refreshes and identity assessments are separate from scientific content review.
One of the original Bowers-lab growth hormone-releasing peptides that seeded the entire GHRP class.
Also known as: GHRP1 · growth hormone-releasing peptide 1
Part of the Growth hormone & IGF peptides cluster
Overview
GHRP-1 is a synthetic growth hormone-releasing peptide developed from enkephalin-analog research and acting at the ghrelin/GHS receptor. It belongs to the same secretagogue family as GHRP-2, GHRP-6 and hexarelin and is studied in growth-hormone-axis research. It is not authorized by Health Canada for therapeutic use.
Source & context
Biological / chemical source: Synthetic met-enkephalin-derived GHRP
Primary research or clinical context: Research compound (not authorized by Health Canada)
Place in the GHRP family
GHRP-1 was among the earliest peptidyl growth hormone secretagogues synthesized after the discovery that enkephalin-amide analogs could release GH. It is closely related to GHRP-2, GHRP-6 and hexarelin, sharing the ghrelin-receptor mechanism rather than any sequence homology with GHRH.
Research framing
Published work examines GH release, receptor pharmacology and possible cytoprotective signaling across the GHRP class. Human clinical use is limited, and online protocols are not a substitute for controlled research design or licensed medical care. This page is educational only.
Structure & chemistry
Molecular identity & reference confidence
Source-supported reference
Reference values are taken from the cited molecular record or curated profile. A database match is not independent laboratory verification; modifications, counter-ions, and formulations can change the measured mass.
- Molecular form
- GHRP-1 (source record; form not independently established)
- Species
- Not established by this molecular identity audit
- Termini (N / C)
- Not specified / Not specified
Average reference mass
Reference policy updated: 2026-10-05
- PubChem molecular record · 2026-10-01
- Molecular formula
- C51H62N12O7
- Average reference mass
- ≈ 955.1
- PubChem CID: 10350910
- CAS RN: 141925-59-9
- UNII: 39EVI31P0W
Chemistry values: PubChem · fetched 2026-10-01.
Clinical development snapshot
ClinicalTrials.gov lists 1 registered study with “GHRP-1” as an intervention (snapshot 2026-09-06). A registry footprint is not evidence of efficacy or approval.
| NCT | Title | Phase | Status | Updated |
|---|---|---|---|---|
| NCT00381602 | A Phase II, Randomized, Cross-Over, Vehicle-Controlled, Double-Blind, Multicenter Study of the Safety, Pharmac | Phase 2 | terminated | 2011-04-04 |
GHRP-1 — reconstitution calculator
Enter how much peptide is in the vial and how much diluent (e.g. bacteriostatic water) is added. The tool returns the resulting solution concentration — and, for any amount you type, the volume it corresponds to. This is educational arithmetic, not a dosing recommendation.
Reference form: GHRP-1 (source record; form not independently established)Average reference mass: 955.1 Da
Enter an amount to see the volume it corresponds to.
Educational concentration mathematics only. This tool does not recommend a dose, amount, or protocol, and nothing here is medical advice. Many peptides are not authorized by Health Canada for human use — see our reconstitution and bacteriostatic-water guides for context.
FAQ about GHRP-1
What is GHRP-1?+
GHRP-1 is a synthetic growth hormone-releasing peptide developed from enkephalin-analog research and acting at the ghrelin/GHS receptor. It belongs to the same secretagogue family as GHRP-2, GHRP-6 and hexarelin and is studied in growth-hormone-axis research. It is not authorized by Health Canada for therapeutic use.
What Canadian product status is recorded for GHRP-1?+
Canadian product status for GHRP-1 has not been verified in this profile. No verified record here does not mean no authorization exists. Status depends on the product, formulation and use; consult Health Canada's product records.
What is the typical length of GHRP-1?+
GHRP-1 is commonly described as approximately 7 amino acids (Research peptide).
Related peptides
References & further reading
- 1.Wu et al. (1994). Effects in vitro of new growth hormone releasing peptide (GHRP-1) on growth hormone secretion from ovine pituitary cells in primary culture. J Neuroendocrinol
- 2.Semenistaya et al. (2015). Determination of growth hormone releasing peptides metabolites in human urine after nasal administration of GHRP-1, GHRP-2, GHRP-6, Hexarelin, and Ipamorelin. Drug Test Anal
- 3.Charrier et al. (1998). In vivo effects of the GH-releasing heptapeptide GHRP-1 in lambs. Reprod Nutr Dev
- 4.DrugBank — Growth hormone-releasing peptide 1 (DB19259)
- 5.PMC — Synthetic Growth Hormone-Releasing Peptides (GHRPs): A Historical Appraisal