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Signaling peptide (chromogranin-derived)

Catestatin

Catestatin is a 21-amino-acid peptide cleaved from chromogranin A and released from neuroendocrine secretory granules. As a non-competitive nicotinic-cholinergic antagonist, it inhibits catecholamine (adrenaline/noradrenaline) release and is studied in blood-pressure regulation, metabolism and immunity. This page is educational and not medical advice.

By The Peptides Codex Editorial TeamReviewed July 10, 2026
Length
21 aa
Class
Signaling peptide (chromogranin-derived)
Function
Non-competitive nicotinic antagonist; inhibits catecholamine release
Context
Autonomic, cardiovascular and metabolic physiology research

A 21-residue chromogranin-A fragment that brakes catecholamine secretion and lowers blood pressure.

Also known as: CST · chromogranin A-derived peptide

Part of the Foundational & therapeutic peptides cluster

Overview

Catestatin is a 21-amino-acid peptide cleaved from chromogranin A and released from neuroendocrine secretory granules. As a non-competitive nicotinic-cholinergic antagonist, it inhibits catecholamine (adrenaline/noradrenaline) release and is studied in blood-pressure regulation, metabolism and immunity. This page is educational and not medical advice.

Source & context

Biological / chemical source: Cleaved from chromogranin A (CHGA gene) in secretory granules

Primary research or clinical context: Autonomic, cardiovascular and metabolic physiology research

Origin and mechanism

Chromogranin A is processed into several bioactive peptides, including vasostatin, pancreastatin and catestatin. Catestatin acts as a non-competitive antagonist at nicotinic acetylcholine receptors on chromaffin cells, providing autocrine feedback that dampens catecholamine secretion.

Physiological interest

Reduced catestatin and impaired chromogranin-A processing are reported in hypertension and in normotensive individuals at genetic risk. Research also links catestatin to insulin sensitivity, cardiac function, antimicrobial defense and inflammation, marking it a multifunctional signaling peptide.

FAQ about Catestatin

What is Catestatin?+

Catestatin is a 21-amino-acid peptide cleaved from chromogranin A and released from neuroendocrine secretory granules. As a non-competitive nicotinic-cholinergic antagonist, it inhibits catecholamine (adrenaline/noradrenaline) release and is studied in blood-pressure regulation, metabolism and immunity. This page is educational and not medical advice.

Is Catestatin an approved medicine?+

Catestatin is discussed here as a research / educational topic. Autonomic, cardiovascular and metabolic physiology research. This is not medical advice.

What is the typical length of Catestatin?+

Catestatin is commonly described as approximately 21 amino acids (Signaling peptide (chromogranin-derived)).

Related peptides

Guanylin
Signaling peptide (guanylin family)
Guanylin is a 15-amino-acid peptide secreted by goblet cells of the colon and encoded by GUCA2A. As an endogenous agonist of the guanylate cyclase-C (GC-C) receptor, it raises intracellular cGMP to regulate intestinal chloride, bicarbonate and water transport. This page is educational and not medical advice.
Uroguanylin
Signaling peptide (guanylin family)
Uroguanylin is a 16-amino-acid peptide secreted by enterochromaffin cells of the duodenum and encoded by GUCA2B. As an endogenous guanylate cyclase-C agonist, it regulates intestinal and renal electrolyte and water transport and has been implicated in appetite and post-meal fullness. This page is educational and not medical advice.
Phoenixin
Neuropeptide
Phoenixin (PNX) is a highly conserved neuropeptide first described in 2013 and processed from the SMIM20 prohormone into 14- and 20-residue forms. Signaling through the GPR173 receptor, it is studied for roles in reproduction, appetite, anxiety and energy metabolism. This page is educational and not medical advice.
BPC-157
Research peptide
BPC-157 (Body Protection Compound-157) is a synthetic 15-amino-acid peptide studied in preclinical models of tissue repair and gastrointestinal protection. It is not an approved therapeutic in Canada or the United States.

References & further reading

  1. 1.PMC — Catestatin: A multifunctional peptide from chromogranin A
  2. 2.GeneCards — CHGA gene (Chromogranin A)
Disclaimer: Educational content only. Not medical advice. Not instructions for human use. Research peptides and unapproved products may be restricted or illegal to market for human consumption in your jurisdiction. Consult qualified professionals and applicable law.
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Cite this: Peptides Codex — Catestatin educational profile.
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