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Signaling peptide (chromogranin-derived)

Catestatin

Catestatin is a 21-amino-acid peptide cleaved from chromogranin A and released from neuroendocrine secretory granules.

By The Peptides Codex Editorial TeamIndividual review date not recorded

Page data last changed: . Chemistry registry snapshot: . Registry refreshes and identity assessments are separate from scientific content review.

Length
21 aa
Class
Signaling peptide (chromogranin-derived)
Function
Non-competitive nicotinic antagonist; inhibits catecholamine release
Context
Autonomic, cardiovascular and metabolic physiology research

A 21-residue chromogranin-A fragment that brakes catecholamine secretion and lowers blood pressure.

Also known as: CST · chromogranin A-derived peptide

Part of the Foundational & therapeutic peptides cluster

Overview

Catestatin is a 21-amino-acid peptide cleaved from chromogranin A and released from neuroendocrine secretory granules. As a non-competitive nicotinic-cholinergic antagonist, it inhibits catecholamine (adrenaline/noradrenaline) release and is studied in blood-pressure regulation, metabolism and immunity. This page is educational and not medical advice.

Source & context

Biological / chemical source: Cleaved from chromogranin A (CHGA gene) in secretory granules

Primary research or clinical context: Autonomic, cardiovascular and metabolic physiology research

Origin and mechanism

Chromogranin A is processed into several bioactive peptides, including vasostatin, pancreastatin and catestatin. Catestatin acts as a non-competitive antagonist at nicotinic acetylcholine receptors on chromaffin cells, providing autocrine feedback that dampens catecholamine secretion.

Physiological interest

Reduced catestatin and impaired chromogranin-A processing are reported in hypertension and in normotensive individuals at genetic risk. Research also links catestatin to insulin sensitivity, cardiac function, antimicrobial defense and inflammation, marking it a multifunctional signaling peptide.

Structure & chemistry

Molecular identity & reference confidence

Source-supported reference

Reference values are taken from the cited molecular record or curated profile. A database match is not independent laboratory verification; modifications, counter-ions, and formulations can change the measured mass.

Molecular form
Catestatin (source record; form not independently established)
Species
Not established by this molecular identity audit
Termini (N / C)
Not specified / Not specified

Average reference mass

Reference policy updated: 2026-10-05

Molecular formula
C104H164N32O27S
Average reference mass
≈ 2,326.7
Identifiers

Chemistry values: PubChem, IUPHAR/BPS Guide to Pharmacology · fetched 2026-10-01.

Clinical development snapshot

ClinicalTrials.gov lists 24 registered studies with “Catestatin” as an intervention (snapshot 2026-10-01). A registry footprint is not evidence of efficacy or approval.

Registered studies
24
Highest phase reached
Phase 4
Active in latest 100
8
Most recent update
2026-09-15
Most recently updated studies
NCTTitlePhaseStatusUpdated
NCT07819422Acute Effects of HIIT and MICT on Catestatin Dynamics in Young MalesNot applicablecompleted2026-09-15
NCT07591493Adjuvant Trial in Pancreatic Neuroendocrine TumorsPhase 3not yet recruiting2026-05-15
NCT06406387ATRX/DAXX in EUS-FNB Specimens of Pan-NETs—active not recruiting2026-01-13
NCT03017794Evaluation of Neuroendocrine Differentiation as a Potential Mechanism of Tumor Recurrence Following Radiothera—active not recruiting2026-01-06
NCT07209644Catestatin as a Novel Biomarker for Cardiovascular and Microvascular Involvement in Systemic Sclerosis—not yet recruiting2025-10-07
NCT07158125Pathogenesis of Periodontal Disease in Individuals With Psoriasis—not yet recruiting2025-09-05
See all on ClinicalTrials.gov →
Concentration math

Catestatin — reconstitution calculator

Enter how much peptide is in the vial and how much diluent (e.g. bacteriostatic water) is added. The tool returns the resulting solution concentration — and, for any amount you type, the volume it corresponds to. This is educational arithmetic, not a dosing recommendation.

Reference form: Catestatin (source record; form not independently established)Average reference mass: 2,326.7 Da

Syringe graduation
Solution concentration
5 mg/mL5,000 mcg/mL
mcg

Enter an amount to see the volume it corresponds to.

Educational concentration mathematics only. This tool does not recommend a dose, amount, or protocol, and nothing here is medical advice. Many peptides are not authorized by Health Canada for human use — see our reconstitution and bacteriostatic-water guides for context.

Open the Catestatin calculator on its own page →

Change log

Dated observations from the data pipeline (registry flags, trial footprints, identifiers) and editorial reviews of this profile.

  1. Trials1 registered study added on ClinicalTrials.gov (now 24).

FAQ about Catestatin

What is Catestatin?+

Catestatin is a 21-amino-acid peptide cleaved from chromogranin A and released from neuroendocrine secretory granules. As a non-competitive nicotinic-cholinergic antagonist, it inhibits catecholamine (adrenaline/noradrenaline) release and is studied in blood-pressure regulation, metabolism and immunity. This page is educational and not medical advice.

What Canadian product status is recorded for Catestatin?+

Canadian product status for Catestatin has not been verified in this profile. No verified record here does not mean no authorization exists. Status depends on the product, formulation and use; consult Health Canada's product records.

What is the typical length of Catestatin?+

Catestatin is commonly described as approximately 21 amino acids (Signaling peptide (chromogranin-derived)).

Related peptides

Guanylin
Signaling peptide (guanylin family)
Guanylin is a 15-amino-acid peptide secreted by goblet cells of the colon and encoded by GUCA2A. As an endogenous agonist of the guanylate cyclase-C (GC-C) receptor, it raises intracellular cGMP to regulate intestinal chloride, bicarbonate and water transport. This page is educational and not medical advice.
Uroguanylin
Signaling peptide (guanylin family)
Uroguanylin is a 16-amino-acid peptide secreted by enterochromaffin cells of the duodenum and encoded by GUCA2B. As an endogenous guanylate cyclase-C agonist, it regulates intestinal and renal electrolyte and water transport and has been implicated in appetite and post-meal fullness. This page is educational and not medical advice.
Phoenixin
Neuropeptide
Phoenixin (PNX) is a highly conserved neuropeptide first described in 2013 and processed from the SMIM20 prohormone into 14- and 20-residue forms. Signaling through the GPR173 receptor, it is studied for roles in reproduction, appetite, anxiety and energy metabolism. This page is educational and not medical advice.
BPC-157
Research pentadecapeptide (gastric-juice-derived sequence)
BPC-157 (Body Protection Compound-157) is a synthetic 15-residue peptide, GEPPPGKPADDAGLV, derived from a sequence found in human gastric juice. Hundreds of rodent studies, most from a single Zagreb group, report accelerated healing of tendon, muscle, ligament, gut and skin injuries via VEGFR2, nitric-oxide and ERK1/2 pathways. Human evidence is limited to a small safety study and a retrospective chart review; the first phase 2 efficacy trial began recruiting in 2026. It is not approved anywhere and the FDA barred it from compounding in 2023.

References & further reading

  1. 1.Garg et al. (2023). Chromogranin A-derived peptides pancreastatin and catestatin: emerging therapeutic target for diabetes. Amino Acids
  2. 2.Pasqua et al. (2017). Biological Roles of the Eclectic Chromogranin-A-derived Peptide Catestatin. Curr Med Chem
  3. 3.Mahata et al. (2010). Catestatin: a multifunctional peptide from chromogranin A. Regul Pept
  4. 4.Bralewska et al. (2024). The Role of Catestatin in Preeclampsia. Int J Mol Sci
  5. 5.Peng et al. (2025). Improvement of atopic dermatitis-like symptoms in a murine model via the chromogranin A-derived peptide catestatin. Allergol Int
  6. 6.Bourebaba et al. (2021). Catestatin peptide of chromogranin A as a potential new target for several risk factors management in the course of metabolic syndrome. Biomed Pharmacother
  7. 7.Höglund et al. (2020). The chromogranin A-derived peptides catestatin and vasostatin in dogs with myxomatous mitral valve disease. Acta Vet Scand
  8. 8.Jati et al. (2023). Catestatin: Antimicrobial Functions and Potential Therapeutics. Pharmaceutics
  9. 9.PMC — Catestatin: A multifunctional peptide from chromogranin A
  10. 10.GeneCards — CHGA gene (Chromogranin A)
Disclaimer: Educational content only. Not medical advice. Not instructions for human use. Research peptides and unapproved products may be restricted or illegal to market for human consumption in your jurisdiction. Consult qualified professionals and applicable law.
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